Publication Name	World Journal of Gastroenterology
Manuscript ID	5789
Country	Switzerland

Received	2013-09-25 12:48
Peer-Review Started	2013-09-25 16:56
To Make the First Decision	2013-12-26 10:56
Return for Revision	2014-01-17 10:19
Revised
Second Decision	2014-04-23 08:58
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-04-23 10:01
Articles in Press	2014-05-23 11:10
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-05-01 16:31
Typeset the Manuscript	2014-06-08 12:54
Publish the Manuscript Online	2014-06-21 13:56

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Recurrent Clostridium difficile infections: The importance of the intestinal microbiota
Manuscript Source	Invited Manuscript
All Author List	Marie Céline Zanella Terrier, Martine Louis Simonet, Philippe Bichard and Jean Louis Frossard
Funding Agency and Grant Number
Corresponding Author	Jean Louis Frossard, MD, Service of Gastroenterology and Hepatology, Geneva University Hospital, Rue Gabrielle-Perret-Gentil 4, 1211 Geneva, Switzerland. jean-louis.frossard@hcuge.ch
Key Words	Clostridium difficile infection; Clostridium difficile recurrence; fecal microbiota transplantation; ; stool transplantation; microbiota
Core Tip	Despite current antibiotic treatments, Clostridium difficile infection (CDI) is a growing epidemic with increasing rates of recurrence, severity and mortality. The treatment of recurrent CDI thus represents a real challenge. This article simultaneously focuses on current guidelines for CDI treatment, the role of gut microbiota in CDI recurrence and current evidence about fecal microbiota transplantation (FMT) efficacy, adverse effects and acceptability. According to studies published to date, FMT use for recurrent CDI is associated with high resolution rates compared with standard antibiotic treatment. Further studies are needed to confirm FMT effectiveness, and to determine the long-term consequences and good administration practices.
Publish Date	2014-06-21 13:56
Citation	Zanella Terrier MC, Simonet ML, Bichard P, Frossard JL. Recurrent Clostridium difficile infections: The importance of the intestinal microbiota. World J Gastroenterol 2014; 20(23): 7416-7423
URL	http://www.wjgnet.com/1007-9327/full/v20/i23/7416.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i23.7416

Full Article (PDF)	WJG-20-7416.pdf
Full Article (Word)	WJG-20-7416.doc
Manuscript File	5789-Review.doc
Answering Reviewers	5789-Answering reviewers.pdf
Copyright License Agreement	5789-Copyright assignment.pdf
Peer-review Report	5789-Peer reviews.pdf
Scientific Editor Work List	5789-Scientific editor work list.doc