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Articles Published Processes
1/23/2021 5:21:26 AM | Browse: 594 | Download: 1794
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Received |
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2020-06-28 10:44 |
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Peer-Review Started |
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2020-06-28 10:45 |
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To Make the First Decision |
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Return for Revision |
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2020-10-21 20:32 |
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Revised |
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2020-11-30 15:35 |
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Second Decision |
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2020-12-10 11:48 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-12-10 20:35 |
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Articles in Press |
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2020-12-10 20:35 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-12-22 08:39 |
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Typeset the Manuscript |
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2021-01-22 00:24 |
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Publish the Manuscript Online |
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2021-01-23 05:21 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Basic Study |
| Article Title |
Role of ferroptosis in the process of diabetes-induced endothelial dysfunction
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Er-Fei Luo, Hong-Xia Li, Yu-Han Qin, Yong Qiao, Gao-Liang Yan, Yu-Yu Yao, Lin-Qing Li, Jian-Tong Hou, Cheng-Chun Tang and Dong Wang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81800244 |
| National Natural Science Foundation of China |
81670237 |
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| Corresponding Author |
Dong Wang, PhD, Doctor, Doctor, Department of Cardiology, Zhongda Hospital, Southeast University, No. 87 Dingjiaqiao, Gulou District, Nanjing 210009, Jiangsu Province, China. wangdong_seu@163.com |
| Key Words |
Diabetes mellitus; Endothelial dysfunction; Ferroptosis; Reactive oxygen species; p53; Glutathione |
| Core Tip |
Endothelial dysfunction is a critical and initiating contributor to the pathogenesis of diabetic cardiovascular complications. Ferroptosis is characterized by the accumulation of iron-induced lipid reactive oxygen species and depletion of plasma membrane unsaturated fatty acids our findings demonstrated that ferroptosis is involved in endothelial dysfunction and the p53-x-ray-computed tomography-glutathione axis activation plays a crucial role in endothelial cell ferroptosis and endothelial dysfunction. The results provide important insights that inhibiting the activation of the p53-x-ray-computed tomography-glutathione axis and ferroptosis could attenuate diabetes-induced endothelial dysfunction and could be a novel strategy for the treatment of vascular complications in diabetes mellitus. |
| Publish Date |
2021-01-23 05:21 |
| Citation |
Luo EF, Li HX, Qin YH, Qiao Y, Yan GL, Yao YY, Li LQ, Hou JT, Tang CC, Wang D. Role of ferroptosis in the process of diabetes-induced endothelial dysfunction. World J Diabetes 2021; 12(2): 124-137 |
| URL |
https://www.wjgnet.com/1948-9358/full/v12/i2/124.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v12.i2.124 |
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