Publication Name	World Journal of Stem Cells
Manuscript ID	57903
Country	China

Received	2020-07-01 13:46
Peer-Review Started	2020-07-01 13:47
To Make the First Decision
Return for Revision	2020-07-30 19:12
Revised	2020-09-06 16:51
Second Decision	2020-09-27 06:52
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2020-09-28 05:04
Articles in Press	2020-09-28 05:04
Publication Fee Transferred
Edit the Manuscript by Language Editor	2020-10-16 02:30
Typeset the Manuscript	2020-11-20 11:23
Publish the Manuscript Online	2020-11-26 10:14

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Biochemistry & Molecular Biology
Manuscript Type	Review
Article Title	Advance in metabolism and target therapy in breast cancer stem cells
Manuscript Source	Invited Manuscript
All Author List	Xu Gao and Qiong‐Zhu Dong
ORCID	Author(s) ORCID Number Xu Gao http://orcid.org/0000-0001-8757-0126 Qiong‐Zhu Dong http://orcid.org/0000-0002-2433-7199
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81772563
Corresponding Author	Xu Gao, MD, Doctor, Doctor, Department of Breast Surgery, YiWu Maternity and Children Hospital, No. C-100 Xinke Road, Yiwu 322000, Zhejiang Province, China. gao.xu.199@gmail.com
Key Words	Breast cancer; Cancer stem cells; Metabolism; Oxidative phosphorylation; Tumor relapse; Target therapy
Core Tip	Breast cancer is thought to be driven by breast cancer stem cells (BCSCs). Recent studies suggest that BCSCs are essential for tumor progression, and tumor relapse, thus triggering therapeutic resistance of breast cancer after the traditional therapies. Moreover, the metabolic features of breast cancer cells are different from those of normal cells. BCSCs alter their metabolic profiles to fulfil bioenergetic and biosynthetic demands to maintain cancer cells survival. Here, we review the research regarding metabolism and target therapy in BCSCs.
Publish Date	2020-11-26 10:14
Citation	Gao X, Dong QZ. Advance in metabolism and target therapy in breast cancer stem cells. World J Stem Cells 2020; 12(11): 1295-1306
URL	https://www.wjgnet.com/1948-0210/full/v12/i11/1295.htm
DOI	https://dx.doi.org/10.4252/wjsc.v12.i11.1295

Full Article (PDF)	WJSC-12-1295.pdf
Full Article (Word)	WJSC-12-1295.docx
Manuscript File	57903_Auto_Edited_WangTQ.docx
Answering Reviewers	57903-Answering reviewers.pdf
Audio Core Tip	57903-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	57903-Conflict-of-interest statement.pdf
Copyright License Agreement	57903-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	57903-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	57903-Language certificate.pdf
Peer-review Report	57903-Peer-review(s).pdf
Scientific Misconduct Check	57903-CrossCheck.png
Scientific Misconduct Check	57903-Bing-Gong ZM-2.png
Scientific Misconduct Check	57903-Scientific misconduct check.pdf
Scientific Editor Work List	57903-Scientific editor work list.pdf
CrossCheck Report	57903-CrossCheck report.pdf