Publication Name	World Journal of Stem Cells
Manuscript ID	57971
Country	Taiwan

Received	2020-07-21 10:43
Peer-Review Started	2020-07-20 03:33
To Make the First Decision
Return for Revision	2020-10-21 20:14
Revised	2020-11-04 16:26
Second Decision	2020-11-12 09:34
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2020-11-12 17:33
Articles in Press	2020-11-12 17:33
Publication Fee Transferred
Edit the Manuscript by Language Editor	2020-11-26 03:11
Typeset the Manuscript	2021-01-18 06:24
Publish the Manuscript Online	2021-01-21 03:12

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Transplantation
Manuscript Type	Basic Study
Article Title	Stem cell transplantation and/or adenoviral glial cell line-derived neurotrophic factor promoted functional recovery in hemiparkinsonian rats
Manuscript Source	Invited Manuscript
All Author List	May-Jywan Tsai, Shih-Chieh Hung, Ching-Feng Weng, Su-Fen Fan, Dann-Ying Liou, Wen-Cheng Huang, Kang-Du Liu and Henrich Cheng
ORCID	Author(s) ORCID Number May-Jywan Tsai http://orcid.org/0000-0001-6353-2475 Shih-Chieh Hung http://orcid.org/0000-0003-1813-4616 Ching-Feng Weng http://orcid.org/0000-0002-9747-8697 Su-Fen Fan http://orcid.org/0000-0002-1596-3972 Dann-Ying Liou http://orcid.org/0000-0001-7391-9868 Wen-Cheng Huang http://orcid.org/0000-0003-0605-5793 Kang-Du Liu http://orcid.org/0000-0003-3883-9955 Henrich Cheng http://orcid.org/0000-0001-9393-7422
Funding Agency and Grant Number	Funding Agency Grant Number Taipei Veterans General Hospital in Taiwan V106C-012, V107C-087 and V109C-018 Ministry of Science and Technology in Taiwan MOST106-2314-B-075-023 Ministry of Science and Technology in Taiwan MOST107-2314-B-010-023 Ministry of Science and Technology in Taiwan MOST107-2314-B-075-021
Corresponding Author	Henrich Cheng, MD, PhD, Full Professor, Surgeon, Department of Neurosurgery, Taipei Veterans General Hospital, Center for Neural Regeneration, Neurological Institute, No. 322 Section 2, Shih-Pai Road, Beitou District, Taipei 112, Taiwan. hc_cheng@vghtpe.gov.tw
Key Words	Stem cells; Transplantation; Parkinson’s disease; Glial cell line-derived neurotrophic factor; Adenovirus; Neuroregeneration
Core Tip	Strategies to stop neurodegeneration in Parkinson’s disease are currently unavailable. In the present study, transplantation of neurally induced mesenchymal stem cells or overexpressing glial cell line-derived neurotrophic factor to the substantia nigra of hemiparkinsonian rats not only exerted a regenerative effect, but promoted functional restoration.  This treatment may have the potential to improve clinical outcome.
Publish Date	2021-01-21 03:12
Citation	Tsai MJ, Hung SC, Weng CF, Fan SF, Liou DY, Huang WC, Liu KD, Cheng H. Stem cell transplantation and/or adenoviral glial cell line-derived neurotrophic factor promoted functional recovery in hemiparkinsonian rats. World J Stem Cells 2021; 13(1): 78-90
URL	https://www.wjgnet.com/1948-0210/full/v13/i1/78.htm
DOI	https://dx.doi.org/10.4252/wjsc.v13.i1.78

Full Article (PDF)	WJSC-13-78.pdf
Full Article (Word)	WJSC-13-78.docx
The ARRIVE Guidelines	57971-The-ARRIVE-Guidelines-revision.pdf
Manuscript File	57971_Auto_Edited_WangTQ.docx
Answering Reviewers	57971-Answering reviewers.pdf
Audio Core Tip	57971-Audio core tip.wav
Biostatistics Review Certificate	57971-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	57971-Conflict-of-interest statement.pdf
Copyright License Agreement	57971-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	57971-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	57971-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	57971-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	57971-Language certificate.pdf
Supplementary Material	57971-Supplementary material.pdf
Peer-review Report	57971-Peer-review(s).pdf
Scientific Misconduct Check	57971-Scientific misconduct check.pdf
Scientific Editor Work List	57971-Scientific editor work list.pdf
CrossCheck Report	57971-CrossCheck report.pdf