| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Signature based on molecular subtypes of deoxyribonucleic acid methylation predicts overall survival in gastric cancer
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jin Bian, Jun-Yu Long, Xu Yang, Xiao-Bo Yang, Yi-Yao Xu, Xin Lu, Xin-Ting Sang and Hai-Tao Zhao |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| International Science and Technology Cooperation Projects |
2016YFE0107100 |
| Capital Special Research Project for Health Development |
2014-2-4012 |
| Beijing Natural Science Foundation |
L172055 |
| Beijing Natural Science Foundation |
7192158 |
| National Ten-thousand Talent Program, the Fundamental Research Funds for the Central Universities |
3332018032 |
| CAMS Innovation Fund for Medical Science (CIFMS) |
2017-I2M-4-003 |
| CAMS Innovation Fund for Medical Science (CIFMS) |
2018-I2M-3-001 |
|
| Corresponding Author |
Hai-Tao Zhao, MD, Professor, Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS and PUMC), Beijing, China, No. 1 Shuaifuyuan, Wangfujing, Beijing 100730, China. zhaoht@pumch.cn |
| Key Words |
Gastric cancer; Deoxyribonucleic acid methylation; Molecular subtypes; Prognosis; Risk score; The Cancer Genome Atlas |
| Core Tip |
To address the epigenetic heterogeneity of gastric cancer, three subgroups based on Deoxyribonucleic acid methylation were identified and each subtype was associated with distinct survival and clinical features. A signature based on molecular subtypes of Deoxyribonucleic acid methylation was built to predict the survival of gastric cancer patients, and showed good performance. This work may improve our understanding of the epigenetic landscape of gastric cancer and facilitate precision medicine for these patients. |
| Publish Date |
2020-11-06 07:36 |
| Citation |
Bian J, Long JY, Yang X, Yang XB, Xu YY, Lu X, Sang XT, Zhao HT. Signature based on molecular subtypes of deoxyribonucleic acid methylation predicts overall survival in gastric cancer. World J Gastroenterol 2020; 26(41): 6414-6430 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i41/6414.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i41.6414 |
