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Articles Published Processes
9/17/2020 1:56:14 AM | Browse: 888 | Download: 2639
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Received |
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2020-07-06 00:32 |
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Peer-Review Started |
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2020-07-06 00:33 |
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To Make the First Decision |
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Return for Revision |
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2020-07-28 18:22 |
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Revised |
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2020-08-07 10:22 |
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Second Decision |
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2020-08-25 09:52 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-08-25 22:01 |
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Articles in Press |
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2020-08-25 22:01 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-08-30 19:33 |
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Typeset the Manuscript |
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2020-09-15 00:40 |
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Publish the Manuscript Online |
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2020-09-17 01:56 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Surgery |
| Manuscript Type |
Retrospective Study |
| Article Title |
RBBP4 promotes colon cancer malignant progression via regulating Wnt/β-catenin pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yan-Dong Li, Zhen Lv and Wei-Fang Zhu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Zhejiang Provincial Natural Science Foundation of China |
LY20H030011 |
| Zhejiang Provincial Natural Science Foundation of China |
LQ18H160011 |
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| Corresponding Author |
Wei-Fang Zhu, MD, Assistant Professor, Division of Dermatology, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. wfzhu@163.com |
| Key Words |
Colon cancer; Wnt/β-catenin; RBBP4; Epithelial-mesenchymal transition; Apoptosis; Invasion |
| Core Tip |
Our previous study demonstrated upregulation of RBBP4 in colon cancer and correlation of poor prognosis with colon cancer and hepatic metastasis. This study explored the potential biological function of RBBP4 in colon cancer. We found that RBBP4 was highly expressed in colon cancer cell lines. Knockdown of RBBP4 significantly inhibited cell proliferation and surviving-mediated apoptosis, and suppressed nuclear translocation of β-catenin. RBBP4 inhibition reduced cell invasion and migration via regulating proteins related to epithelial–mesenchymal transition. Mechanistically, RBBP4 knockdown increased activity of the Wnt/β-catenin pathway. With Wnt/β-catenin activator, the role of RBBP4 in colon cancer progression was dependent on Wnt/β-catenin pathway. RBBP4 may serve as a novel therapeutic target in colon cancer. |
| Publish Date |
2020-09-17 01:56 |
| Citation |
Li YD, Lv Z, Zhu WF. RBBP4 promotes colon cancer malignant progression via regulating Wnt/β-catenin pathway. World J Gastroenterol 2020; 26(35): 5328-5342 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i35/5328.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i35.5328 |
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