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Articles Published Processes
11/26/2020 10:14:32 AM | Browse: 778 | Download: 1648
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Received |
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2020-07-10 09:24 |
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Peer-Review Started |
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2020-07-10 09:25 |
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To Make the First Decision |
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Return for Revision |
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2020-08-09 14:56 |
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Revised |
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2020-08-19 10:27 |
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Second Decision |
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2020-09-25 10:07 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-09-25 18:58 |
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Articles in Press |
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2020-09-25 18:58 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-10-10 06:57 |
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Typeset the Manuscript |
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2020-11-19 07:49 |
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Publish the Manuscript Online |
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2020-11-26 10:14 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Glutathione metabolism is essential for self-renewal and chemoresistance of pancreatic cancer stem cells
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Petra Jagust, Sonia Alcalá, Bruno Sainz Jr, Christopher Heeschen and Patricia Sancho |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Fondo Investigaciones Sanitarias |
PI17/00082 |
| Instituto de Salud Carlos III and European Funds (FSE: “el FSE invierte en tu futuro” and FEDER: “una manera de hacer Europa”) Miguel Servet Fellowship |
CP16/00121 |
| European Community's Seventh Framework Programme |
602783 |
| ERC Advanced Investigator Program |
Pa-CSC 233460 |
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| Corresponding Author |
Patricia Sancho, PhD, Senior Scientist, Hospital Universitario Miguel Servet, IIS Aragon, Isabel la Católica 1-3, Zaragoza 50009, Spain. psancho@iisaragon.es |
| Key Words |
Pancreatic cancer; Cancer stem cells; Glutathione; Self-renewal; Chemoresistance; Redox |
| Core Tip |
Several glutathione metabolism genes are upregulated in pancreatic cancer stem cells (CSCs), and their expression correlates with a stemness signature and predicts survival in clinical samples. Increased glutathione concentration in CSCs promotes viability, cell cycle progression and pluripotency gene expression. Inhibition of glutathione synthesis or recycling impairs CSC functionalities such as self-renewal and chemoresistance. Our data demonstrate a targetable metabolic vulnerability of this aggressive subpopulation of cancer cells. |
| Publish Date |
2020-11-26 10:14 |
| Citation |
Jagust P, Alcalá S, Sainz Jr B, Heeschen C, Sancho P. Glutathione metabolism is essential for self-renewal and chemoresistance of pancreatic cancer stem cells. World J Stem Cells 2020; 12(11): 1410-1428 |
| URL |
https://www.wjgnet.com/1948-0210/full/v12/i11/1410.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v12.i11.1410 |
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