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Articles Published Processes
9/21/2020 4:02:08 PM | Browse: 664 | Download: 1543
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Received |
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2020-07-08 02:38 |
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Peer-Review Started |
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2020-07-08 02:39 |
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To Make the First Decision |
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Return for Revision |
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2020-07-30 17:50 |
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Revised |
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2020-07-31 20:08 |
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Second Decision |
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2020-08-11 07:20 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-08-15 21:56 |
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Articles in Press |
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2020-08-15 21:56 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-08-24 00:28 |
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Publish the Manuscript Online |
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2020-09-21 16:02 |
ISSN |
1948-5182 (online) |
Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Review |
Article Title |
Clinical implications, diagnosis, and management of diabetes in patients with chronic liver diseases
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Manuscript Source |
Unsolicited Manuscript |
All Author List |
Waihong Chung, Kittichai Promrat and Jack Wands |
ORCID |
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Funding Agency and Grant Number |
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Corresponding Author |
Waihong Chung, MD, PhD, Doctor, Doctor, Research Fellow, Division of Gastroenterology, Department of Medicine, Rhode Island Hospital, 245 Chapman Street, Suite 300, Providence, RI 02905, United States. waihongchung@gmail.com |
Key Words |
End stage liver disease; Diabetes mellitus; Liver cirrhosis; Insulin resistance; Non-alcoholic fatty liver disease; Liver diseases |
Core Tip |
Diabetes is an independent risk factor for the development and progression of chronic liver disease (CLD) of various etiologies. Concurrent diabetes and CLD predict worse clinical outcomes, including hepatic decompensation, hepatocellular carcinoma (HCC), and complications following liver transplantation. Traditional glycemic markers, including fasting glucose, oral glucose tolerance test, and hemoglobin A1c, are not accurate in patients with severe CLD. Metformin and α-glucosidase inhibitors are associated with significant benefits beyond glycemic control, including reductions in HCC risk and incidence of hepatic encephalopathy. Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors may exert a hepatic protective effect irrespective of the degree of glycemic control. |
Publish Date |
2020-09-21 16:02 |
Citation |
Chung W, Promrat K, Wands J. Clinical implications, diagnosis, and management of diabetes in patients with chronic liver diseases. World J Hepatol 2020; 12(9): 533-557 |
URL |
https://www.wjgnet.com/1948-5182/full/v12/i9/533.htm |
DOI |
https://dx.doi.org/10.4254/wjh.v12.i9.533 |
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