Publication Name	World Journal of Gastroenterology
Manuscript ID	5817
Country	Hungary

Received	2013-09-27 06:49
Peer-Review Started	2013-09-27 12:02
To Make the First Decision	2013-12-03 19:12
Return for Revision	2013-12-11 09:20
Revised	2013-12-12 07:07
Second Decision	2014-01-20 17:22
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-01-20 18:22
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-03-06 15:52
Publish the Manuscript Online	2014-03-27 12:04

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Inflammatory bowel disease course in Crohn’s disease: Is the natural history changing?
Manuscript Source	Invited Manuscript
All Author List	Petra A Golovics, Michael D Mandel, Barbara D Lovasz and Peter L Lakatos
Funding Agency and Grant Number
Corresponding Author	Peter Laszlo Lakatos, MD, PhD, First Department of Medicine, Semmelweis University, Koranyi S. 2/A, H-1083 Budapest, Hungary. lakatos.peter_laszlo@med.semmelweis-univ.hu
Key Words	Crohn’s disease; Natural history; Surgery; Mortality; Disease course; Inflammatory bowel disease
Core Tip	Studies on the natural history of Crohn’s disease (CD) provide invaluable data on its course and clinical predictors, and may help to identify patient subsets based on clinical phenotype. New data suggest the possibility of a change in the natural history in CD, with an increasing percentage of patients diagnosed with inflammatory disease behavior. Hospitalization rates remain high, while surgery rates seem to decrease in the last decade. Mortality rates still exceed that of the general population. The impact of changes in treatment strategy, including increased, earlier use of immunosuppressives, biological therapy, and patient monitoring on the natural history of the disease are still conflictive.
Publish Date	2014-03-27 12:04
Citation	Golovics PA, Mandel MD, Lovasz BD, Lakatos PL. Inflammatory bowel disease course in Crohn’s disease: Is the natural history changing? World J Gastroenterol 2014; 20(12): 3198-3207
URL	http://www.wjgnet.com/1007-9327/full/v20/i12/3198.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i12.3198

Full Article (PDF)	WJG-20-3198.pdf
Full Article (Word)	WJG-20-3198.doc
Manuscript File	5817-Review.doc
Answering Reviewers	5817-Answering reviewers.pdf
Copyright License Agreement	5817-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	5817-Language certificate.pdf
Peer-review Report	5817-Peer reviews.pdf
Scientific Editor Work List	5817-Scientific editor work list.doc