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Articles Published Processes
1/21/2021 3:12:07 AM | Browse: 564 | Download: 1233
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Received |
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2020-07-12 23:23 |
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Peer-Review Started |
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2020-07-12 23:23 |
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To Make the First Decision |
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Return for Revision |
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2020-09-24 19:35 |
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Revised |
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2020-11-01 03:52 |
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Second Decision |
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2020-11-17 09:48 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-11-17 22:49 |
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Articles in Press |
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2020-11-17 22:49 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-11-24 23:43 |
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Typeset the Manuscript |
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2021-01-14 01:39 |
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Publish the Manuscript Online |
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2021-01-21 03:12 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Engineering, Biomedical |
| Manuscript Type |
Basic Study |
| Article Title |
Vascularization and osteogenesis in ectopically implanted bone tissue-engineered constructs with endothelial and osteogenic differentiated adipose-derived stem cells
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Jelena G Najdanović, Vladimir J Cvetković, Sanja T Stojanović, Marija Đ Vukelić-Nikolić, Jelena M Živković and Stevo J Najman |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Ministry of Education, Science and Technological Development of the Republic of Serbia |
III41017 |
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| Corresponding Author |
Stevo J Najman, PhD, Full Professor, Department of Biology and Human Genetics; Department for Cell and Tissue Engineering, Faculty of Medicine, University of Niš, Blvd. Dr Zorana Djindjica 81, Niš 18108, Serbia. stevo.najman@medfak.ni.ac.rs |
| Key Words |
Adipose-derived stem cells; Endothelial-related genes; Bone-related genes; Ectopic osteogenesis; Vascularization; Platelet-rich plasma |
| Core Tip |
For successful bone tissue regeneration, osteogenesis and vasculogenesis should be supported by appropriate combination of cells, growth factors and biomaterials (biological triad). Since optimal triad factors composition is still unknown, our aim was to combine endothelial differentiated and osteogenic differentiated adipose-derived stem cells in the same construct together with platelet-rich plasma on bone mineral matrix as a carrier. Ectopic osteogenic potential of this construct was examined in mice subcutaneous implantation model which enables interplay between endothelial cells (ECs) and osteoblasts (OBs) in induction of ectopic osteogenesis. Obtained results unequivocally indicate the potential of such approach for further preclinical evaluations in orthotopic model regarding optimization of ECs/OBs ratio within bone tissue engineering constructs. |
| Publish Date |
2021-01-21 03:12 |
| Citation |
Najdanović JG, Cvetković VJ, Stojanović ST, Vukelić-Nikolić MĐ, Živković JM, Najman SJ. Vascularization and osteogenesis in ectopically implanted bone tissue-engineered constructs with endothelial and osteogenic differentiated adipose-derived stem cells. World J Stem Cells 2021; 13(1): 91-114 |
| URL |
https://www.wjgnet.com/1948-0210/full/v13/i1/91.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v13.i1.91 |
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