Publication Name	World Journal of Gastroenterology
Manuscript ID	5820
Country	Australia

Received	2013-09-27 06:57
Peer-Review Started	2013-09-27 11:49
To Make the First Decision	2013-11-05 09:33
Return for Revision	2013-11-05 09:50
Revised	2013-11-26 08:14
Second Decision	2014-01-06 18:22
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-01-06 18:57
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-01-15 21:01
Publish the Manuscript Online	2014-01-26 20:08

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Medicine, Research & Experimental
Manuscript Type	Topic Highlights
Article Title	Colorectal cancer biomarkers: To be or not to be? Cautionary tales from a road well travelled
Manuscript Source	Invited Manuscript
All Author List	Kim YC Fung, Edouard Nice, Ilka Priebe, Damien Belobrajdic, Aloke Phatak, Leanne Purins, Bruce Tabor, Celine Pompeia, Trevor Lockett, Timothy E Adams, Antony Burgess and Leah Cosgrove
Funding Agency and Grant Number	Funding Agency Grant Number CSIRO Preventative Health National Research Flagship and the National Health and Medical Research Council 1017078
Corresponding Author	Kim YC Fung, PhD, CSIRO, Preventative Health National Research Flagship, PO Box 10041, Adelaide, SA 5000, Australia. kim.fung@csiro.au
Key Words	Biomarker; Bias; Colorectal cancer; Diagnostic; Discovery; Validation
Core Tip	The identification of sensitive and specific biomarkers for the early diagnosis and surveillance of colorectal cancer is recognised as being fundamental to improve survival for this disease. Studies involving analyses of multiple biomarkers require consideration of many potential confounding issues, some of which are impossible or difficult to control for. Implementation of strategies which can overcome and account for potentially confounding variables is essential to ensure robust verification and validation of potential biomarkers and their successful evaluation in large and meaningful clinical cohorts that are representative of the target population, ultimately with successful translation into the clinic.
Publish Date	2014-01-26 20:08
Citation	Fung KYC, Nice E, Priebe I, Belobrajdic D, Phatak A, Purins L, Tabor B, Pompeia C, Lockett T, Adams TE, Burgess A, Cosgrove L. Colorectal cancer biomarkers: To be or not to be? Cautionary tales from a road well travelled. World J Gastroenterol 2014; 20(4): 888-898
URL	http://www.wjgnet.com/1007-9327/full/v20/i4/888.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i4.888

Full Article (PDF)	WJG-20-888.pdf
Full Article (Word)	WJG-20-888.doc
Manuscript File	5820-Review.docx
Answering Reviewers	5820-Answering reviewers.pdf
Copyright License Agreement	5820-Copyright assignment.pdf
Peer-review Report	5820-Peer reviews.pdf
Scientific Editor Work List	5820-Scientific editor work list.doc