Publication Name	World Journal of Neurology
Manuscript ID	5832
Country	Japan

Received	2013-09-28 14:44
Peer-Review Started	2013-09-29 08:52
To Make the First Decision	2013-11-19 12:51
Return for Revision	2013-11-19 13:32
Revised	2013-12-03 23:41
Second Decision	2014-04-09 16:33
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-04-09 16:41
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-04-13 23:18
Typeset the Manuscript	2014-05-05 19:27
Publish the Manuscript Online	2014-05-06 17:55

ISSN	2218-6212 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Neurosciences
Manuscript Type	Editorial
Article Title	Coenzyme Q10 in neurodegenerative disorders: Potential benefit of CoQ10 supplementation for multiple system atrophy
Manuscript Source	Invited Manuscript
All Author List	Hiroshi Takahashi and Kotaro Shimoda
Funding Agency and Grant Number
Corresponding Author	Hiroshi Takahashi, MD, PhD, Department of Neurology, National Hospital Organization, Tottori Medical Center, 876 Mitsu, Tottori 689-0203, Japan. hiroshi@tottori-iryo.hosp.go.jp
Key Words	Primary coenzyme Q10 deficiency; Multiple system atrophy; Cerebellar ataxia; COQ2 gene; Statin; Coenzyme Q10 supplementation; Reduced coenzyme Q10
Core Tip	Recently, multiple system atrophy (MSA), relatively common in adult-onset neurodegenerative diseases, was shown to be linked to mutations in the COQ2 gene, one of the genes involved in the Coenzyme Q10 (CoQ10) biosynthesis pathway. Neurologists so far have not paid much attention to CoQ10 because primary CoQ10 deficiency caused by mutations in the CoQ10 synthesizing genes is very rare. The most important message is that primary CoQ10 deficiency is treatable with exogenous CoQ10 and that oral CoQ10 supplementation might be also beneficial for patients with MSA.
Publish Date	2014-05-06 17:55
Citation	Takahashi H, Shimoda K. Coenzyme Q10 in neurodegenerative disorders: Potential benefit of CoQ10 supplementation for multiple system atrophy. World J Neurol 2014; 4(1): 1-6
URL	http://www.wjgnet.com/2218-6212/full/v4/i1/1.htm
DOI	http://dx.doi.org/10.5316/wjn.v4.i1.1

Full Article (PDF)	WJN-4-1.pdf
Full Article (Word)	WJN-4-1.doc
Manuscript File	5832-Review.docx
Answering Reviewers	5832-Answering reviewers.pdf
Copyright License Agreement	5832-Copyright assignment.pdf
Peer-review Report	5832-Peer review(s).pdf
Scientific Editor Work List	5832-Scientific editor work list.doc