Publication Name	World Journal of Gastroenterology
Manuscript ID	5834
Country	Italy

Received	2013-09-28 14:52
Peer-Review Started	2013-09-29 08:55
To Make the First Decision	2013-12-26 10:55
Return for Revision	2014-01-17 10:07
Revised	2014-01-20 22:15
Second Decision	2014-03-06 17:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-03-06 18:24
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-04-11 18:06
Publish the Manuscript Online	2014-05-14 10:58

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Topic Highlights
Article Title	Obesity and colorectal cancer: Role of adipokines in tumor initiation and progression
Manuscript Source	Invited Manuscript
All Author List	Silvia Riondino, Mario Roselli, Raffaele Palmirotta, David Della-Morte, Patrizia Ferroni and Fiorella Guadagni
Funding Agency and Grant Number
Corresponding Author	Patrizia Ferroni, MD, PhD, Biomarker Discovery and Advanced Technologies (BioDAT) Laboratory, IRCCS San Raffaele Pisana-Research Center, Via di Val Cannuta 247, 00166 Rome, Italy. patrizia.ferroni@sanraffaele.it
Key Words	Obesity; Colorectal cancer; Inflammation; Adiponectin; Leptin; Resistin; Ghrelin; Cytokines
Core Tip	Obesity-associated diseases account for a large portion of public health challenges, and adipose tissue can be regarded as an important and highly active player of the innate immune response, in which cytokine/adipokine secretion is responsible for a paracrine loop between adipocytes and macrophages. This interplay contributes to the systemic chronic low-grade inflammation associated with visceral obesity, which represents a favorable niche for tumor development. Available findings suggest that an unbalanced adipokine profile might serve as a prognostic factor in colorectal cancer patients and that adipokines or their analogues/antagonists might become useful agents in the management or chemoprevention of colon cancer.
Publish Date	2014-05-14 10:58
Citation	Riondino S, Roselli M, Palmirotta R, Della-Morte D, Ferroni P, Guadagni F. Obesity and colorectal cancer: Role of adipokines in tumor initiation and progression. World J Gastroenterol 2014; 20(18): 5177-5190
URL	http://www.wjgnet.com/1007-9327/full/v20/i18/5177.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i18.5177

Full Article (PDF)	WJG-20-5177.pdf
Full Article (Word)	WJG-20-5177.doc
Manuscript File	5834-Review.doc
Answering Reviewers	5834-Answering reviewers.pdf
Copyright License Agreement	5834-Copyright assignment.pdf
Peer-review Report	5834-Peer reviews.pdf
Scientific Editor Work List	5834-Scientific editor work list.doc