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Articles Published Processes
12/18/2020 5:58:43 AM | Browse: 720 | Download: 1511
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Received |
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2020-07-20 15:33 |
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Peer-Review Started |
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2020-07-20 15:35 |
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To Make the First Decision |
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Return for Revision |
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2020-09-24 17:51 |
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Revised |
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2020-10-01 12:52 |
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Second Decision |
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2020-10-26 14:48 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-10-26 18:10 |
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Articles in Press |
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2020-10-26 18:10 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-10-29 23:57 |
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Typeset the Manuscript |
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2020-12-14 01:28 |
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Publish the Manuscript Online |
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2020-12-18 05:58 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Molecular heterogeneity in intrahepatic cholangiocarcinoma
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Keun Soo Ahn and Koo Jeong Kang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Research Foundation of Korea Grant funded by the Korea Government |
2018R1C1B3004435 |
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| Corresponding Author |
Keun Soo Ahn, MD, PhD, Associate Professor, Department of Surgery, Keimyung University Dong-San Medical Center, No. 56, Dalsung-ro, Jung-gu, Daegu 42601, South Korea. ahnksmd@gmail.com |
| Key Words |
Cholangiocarcinoma; Mutation; Gene expression; Pathway; Target therapy; Molecular |
| Core Tip |
Intrahepatic cholangiocarcinoma (iCCA) is a histopathologically and molecularly heterogeneous tumor. Recent developments in genomic profiling have revealed several molecular markers for poor prognosis and activation of oncogenic pathways. Exploration of molecular characteristics of iCCA in each patient is a major challenge in a clinical setting, and still there exists no effective molecular-based targeted therapy. Therefore, the analysis of relevance between molecular and clinicopathological features is very important. The present analysis showed that the molecular subtypes of iCCA have distinct clinicopathologic features and prognostic differences. For developing effective targeted and personalized therapies based on clinical and molecular understanding, future additional large scale researches are necessitated. |
| Publish Date |
2020-12-18 05:58 |
| Citation |
Ahn KS, Kang KJ. Molecular heterogeneity in intrahepatic cholangiocarcinoma. World J Hepatol 2020; 12(12): 1148-1157 |
| URL |
https://www.wjgnet.com/1948-5182/full/v12/i12/1148.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v12.i12.1148 |
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