| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Anesthesiology |
| Manuscript Type |
Randomized Controlled Trial |
| Article Title |
Metalloproteinase expression after desflurane preconditioning in hepatectomies: A randomized clinical trial
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Eleni Koraki, Ioannis Mantzoros, Christos Chatzakis, Anna Gkiouliava, Angeliki Cheva, Athina Lavrentieva, Freideriki Sifaki, Helena Argiriadou, Isaak Kesisoglou, Konstantinos Galanos-Demiris, Stefanos Bitsianis and Konstantinos Tsalis |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Anna Gkiouliava, MD, Doctor, Doctor, Research Fellow, Department of Anaesthesiology, “G Papanikolaou” General Hospital, Exochi,Thessaloniki, Greece, Thessaloniki 57010, Greece. annagkou@auth.gr |
| Key Words |
Desflurane; Preconditioning; Hepatectomy; Inflammation; Metalloproteinases; Reperfusion injury |
| Core Tip |
Ischemia-reperfusion injury remains a leading cause of morbidity and mortality in hepatectomies. In our study, 46 patients were randomly and equally allocated to receive pharmacological preconditioning with desflurane (intervention group) or not (control group) for comparison of the inflammatory indices between the two groups. We found significantly reduced levels of matrix metalloproteinases 2 and 9, increased levels of tissue inhibitor matrix metalloproteinases 1 and 2, and decreased neutrophil infiltration in the intervention group. Thus, hepatoprotective strategies may ameliorate pathophysiologic effects of ischemia-reperfusion during liver surgery, with our study suggesting a novel promising strategy that may benefit patients postoperatively. |
| Publish Date |
2020-11-24 12:41 |
| Citation |
Koraki E, Mantzoros I, Chatzakis C, Gkiouliava A, Cheva A, Lavrentieva A, Sifaki F, Argiriadou H, Kesisoglou I, Galanos-Demiris K, Bitsianis S, Tsalis K. Metalloproteinase expression after desflurane preconditioning in hepatectomies: A randomized clinical trial. World J Hepatol 2020; 12(11): 1098-1114 |
| URL |
https://www.wjgnet.com/1948-5182/full/v12/i11/1098.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v12.i11.1098 |
