Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	58403
Country	Taiwan

Received	2020-08-26 03:56
Peer-Review Started	2020-08-26 03:57
To Make the First Decision
Return for Revision	2020-10-21 18:28
Revised	2020-11-10 02:09
Second Decision	2020-11-17 09:59
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2020-11-17 22:28
Articles in Press	2020-11-17 22:28
Publication Fee Transferred
Edit the Manuscript by Language Editor	2020-11-30 23:56
Typeset the Manuscript	2020-12-09 11:33
Publish the Manuscript Online	2020-12-10 10:17

ISSN	1948-5204 (online)
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Category	Oncology
Manuscript Type	Observational Study
Article Title	Outcomes of neoadjuvant chemoradiotherapy followed by radical resection for T4 colorectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Chun-Ming Huang, Ching-Wen Huang, Cheng-Jen Ma, Hsiang-Lin Tsai, Wei-Chih Su, Tsung-Kun Chang, Ming-Yii Huang and Jaw Yuan Wang
ORCID	Author(s) ORCID Number Chun-Ming Huang http://orcid.org/0000-0002-2605-9639 Ching-Wen Huang http://orcid.org/0000-0001-8011-8428 Cheng-Jen Ma http://orcid.org/0000-0001-8923-9912 Hsiang-Lin Tsai http://orcid.org/0000-0002-1645-2525 Wei-Chih Su http://orcid.org/0000-0002-9336-0667 Tsung-Kun Chang http://orcid.org/0000-0001-9760-5070 Ming-Yii Huang http://orcid.org/0000-0001-9432-5284 Jaw Yuan Wang http://orcid.org/0000-0002-7705-2621
Funding Agency and Grant Number	Funding Agency Grant Number Ministry of Science and Technology MOST109-2314-B-037-035 Ministry of Science and Technology MOST109-2314-B-037-046-MY3 Ministry of Science and Technology MOST109-2314-B-037-040 Ministry of Health and Welfare funded by Health and welfare surcharge of tobacco products MOHW109-TDU-B-212-124026 Kaohsiung Medical University Hospital and the Kaohsiung Municipal Ta-Tung Hospital S10903 Kaohsiung Medical University Hospital and the Kaohsiung Municipal Ta-Tung Hospital KMUH108-8R34 Kaohsiung Medical University Hospital and the Kaohsiung Municipal Ta-Tung Hospital KMUH108-8R35 Kaohsiung Medical University Hospital and the Kaohsiung Municipal Ta-Tung Hospital KMUH108-8M33 Kaohsiung Medical University Hospital and the Kaohsiung Municipal Ta-Tung Hospital KMUH108-8M35 Kaohsiung Medical University Hospital and the Kaohsiung Municipal Ta-Tung Hospital KMUH108-8M36 Kaohsiung Medical University Hospital and the Kaohsiung Municipal Ta-Tung Hospital KMUH-DK109003 Kaohsiung Medical University Hospital and the Kaohsiung Municipal Ta-Tung Hospital KMUH-DK109005-3
Corresponding Author	Jaw Yuan Wang, MD, PhD, Professor, Department of Surgery and Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No. 100, Tz-You 1st Road, Kaohsiung 80708, Taiwan. cy614112@ms14.hinet.net
Key Words	T4; Chemoradiotherapy; Pathological complete response; R0 resection; Colorectal cancer; Survival
Core Tip	Patients with clinical T4 colorectal cancer have a poor prognosis because of compromised surgical margins. This retrospective study demonstrated that neoadjuvant chemoradiotherapy resulted in high rates of pathological complete response and complete resection for patients with T4 colorectal cancer. An aggressive approach that entails implementing the FOLFOX regimen before, during, and after irradiation is safe and can improve pathological complete response rates. Negative resection margins and pathological complete response are significantly associated with survival. th survival.
Publish Date	2020-12-10 10:17
Citation	Huang CM, Huang CW, Ma CJ, Tsai HL, Su WC, Chang TK, Huang MY, Wang JY. Outcomes of neoadjuvant chemoradiotherapy followed by radical resection for T4 colorectal cancer. World J Gastrointest Oncol 2020; 12(12): 1428-1442
URL	https://www.wjgnet.com/1948-5204/full/v12/i12/1428.htm
DOI	https://dx.doi.org/10.4251/wjgo.v12.i12.1428

Full Article (PDF)	WJGO-12-1428.pdf
Full Article (Word)	WJGO-12-1428.docx
STROBE Statement	58403-STROBE-Statement-revision.docx
Manuscript File	58403_Auto_Edited_WangTQ.docx
Answering Reviewers	58403-Answering reviewers.pdf
Audio Core Tip	58403-Audio core tip.m4a
Biostatistics Review Certificate	58403-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	58403-Conflict-of-interest statement.pdf
Copyright License Agreement	58403-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	58403-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	58403-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	58403-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	58403-Language certificate.pdf
Peer-review Report	58403-Peer-review(s).pdf
Scientific Misconduct Check	58403-Bing-Yan JP-1.png
Scientific Misconduct Check	58403-Scientific misconduct check.pdf
Scientific Editor Work List	58403-Scientific editor work list.pdf
CrossCheck Report	58403-CrossCheck Report.pdf