Publication Name	World Journal of Gastroenterology
Manuscript ID	5845
Country	Italy

Received	2013-09-28 15:30
Peer-Review Started	2013-09-29 13:44
To Make the First Decision	2013-10-14 21:08
Return for Revision	2013-10-16 17:07
Revised	2013-10-28 22:23
Second Decision	2013-11-13 12:03
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-11-13 15:15
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-11-27 03:33
Typeset the Manuscript	2013-12-25 08:47
Publish the Manuscript Online	2014-01-20 16:41

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Medicine, Research & Experimental
Manuscript Type	Topic Highlights
Article Title	Hepatitis C virus-related mixed cryoglobulinemia: Is genetics to blame?
Manuscript Source	Invited Manuscript
All Author List	Laura Gragnani, Elisa Fognani, Alessia Piluso and Anna Linda Zignego
Funding Agency and Grant Number	Funding Agency Grant Number “Associazione Italiana per la Ricerca sul Cancro” Investigator Grant 1461 ‘‘Istituto Toscano Tumori’’ “Fondazione Istituto di Ricerche Virologiche Oretta Bartolomei Corsi” “Ente Cassa di Risparmio di Firenze”
Corresponding Author	Anna Linda Zignego, MD, PhD, Center for Systemic Manifestations of Hepatitis Viruses, Department of Experimental and Clinical Medicine, University of Florence, Largo Brambilla 3, 50134 Florence, Italy. a.zignego@dmi.unifi.it
Key Words	Hepatitis C virus; Mixed cryoglobulinemia; Genetics; Viral pathogenetic factors; Host pathogenetic factors
Core Tip	Mixed cryoglobulinemia (MC) is the extrahepatic manifestation most strictly correlated with hepatitis C virus (HCV) infection; it is a benign autoimmune/ lymphoproliferative disorder that evolves to lymphoma in 5%-10% of cases. MC pathogenesis is still poorly understood. Several studies have tried to clarify the pathogenetic basis of MC and have suggested that HCV can trigger such a disorder only in the presence of still-undetermined genetic factors. Here, we attempt to clarify the relationship between HCV-related MC and the host's genetic background. The data that we report are heterogeneous and sometimes conflicting, so large, multicenter studies are clearly needed.
Publish Date	2014-01-20 16:41
Citation	Gragnani L, Fognani E, Piluso A, Zignego AL. Hepatitis C virus-related mixed cryoglobulinemia: Is genetics to blame? World J Gastroenterol 2013; 19(47): 8910-8915
URL	http://www.wjgnet.com/1007-9327/full/v19/i47/8910.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i47.8910

Full Article (PDF)	WJG-19-8910.pdf
Manuscript File	5845-Review.doc
Answering Reviewers	5845-Answering reviewers.pdf
Copyright License Agreement	5845-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	5845-Language certificate.pdf
Peer-review Report	5845-Peer reviews.pdf
Scientific Editor Work List	5845-Scientific editor work list.doc