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Articles Published Processes
9/17/2020 1:56:13 AM | Browse: 762 | Download: 1208
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Received |
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2020-07-22 21:49 |
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Peer-Review Started |
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2020-07-22 21:50 |
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To Make the First Decision |
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Return for Revision |
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2020-08-08 16:37 |
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Revised |
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2020-08-12 23:49 |
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Second Decision |
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2020-09-02 12:27 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-09-03 02:33 |
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Articles in Press |
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2020-09-03 02:33 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-09-15 01:59 |
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Publish the Manuscript Online |
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2020-09-17 01:56 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
Copyright: The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Review |
| Article Title |
Stress granules in colorectal cancer: Current knowledge and potential therapeutic applications
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Noémie Legrand, Dan A Dixon and Cyril Sobolewski |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Geneva Cancer League |
1711 |
| National Institutes of Health |
R01 CA243445 |
| National Cancer Institute Cancer Center Support grant |
P30 CA168524 |
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| Corresponding Author |
Cyril Sobolewski, PhD, Research Associate, Senior Scientist, Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, CMU, 1 rue Michel-Servet, Geneva CH-1211, Switzerland. cyril.sobolewski@unige.ch |
| Key Words |
Stress-Granules; Colorectal cancer; Adenylate-Uridylate-rich element-binding proteins; Post-transcriptional regulation; Oncogenes; Tumor suppressors |
| Core Tip |
Colorectal cancer (CRC) represent the second cause of cancer mortality worldwide. Although changes in genetic landscape associated with CRC development have been identified, most frequent mutations are currently undruggable. The development of chemoresistance represent a major cause of CRC-associated mortality and identifying mechanisms allowing cancer cells to avoid these treatments may considerably improve clinical outcomes. Current findings indicate that cancers cells can preserve their expressed mRNAs in harmful conditions by storing them in small cytoplasmic granules, called Stress granules (SGs), where they are kept translationally silent. Targeting these SGs proteins may therefore represent a novel and efficient therapeutic approach. |
| Publish Date |
2020-09-17 01:56 |
| Citation |
Legrand N, Dixon DA, Sobolewski C. Stress granules in colorectal cancer: Current knowledge and potential therapeutic applications. World J Gastroenterol 2020; 26(35): 5223-5247 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i35/5223.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i35.5223 |
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