| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Autobiography |
| Article Title |
Phase I study of postoperative radiotherapy combined with capecitabine for gastric cancer
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Xin Wang, Jing Jin, Ye-Xiong Li, Hua Ren, Hui Fang, Shu-Lian Wang, Yue-Ping Liu, Wei-Hu Wang, Zi-Hao Yu, Yong-Wen Song and Xin-Fan Liu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Beijing Hope Run Special Fund |
LC2007A03 |
|
| Corresponding Author |
Jing Jin, MD, Department of Radiation Oncology, Cancer Hospital, National Cancer Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Panjiayuan Nanli 17, Chaoyang District, Beijing 100021, China. jingjin1025@163.com |
| Key Words |
Radiotherapy; Capecitabine; Gastric cancer; Maximum tolerated dose; Dose-limiting toxicity |
| Core Tip |
Postoperative chemoradiotherapy is a good option for patients with locally advanced, gastric cancer who have undergone R0 and D0-1 lymphadenectomy. To avoid acute side effects and make the drug safer, a combination of the use of advanced techniques such as intensity modulated radiotherapy and mature chemotherapy regimens with capecitabine is highly recommended, especially in China which accounts for 40% of the world’s gastric cancer patients. The aim of this single-institution, phase I, clinical trial was to assess the feasibility and toxicity of a postoperative regimen involving dose escalation of capecitabine combined with IMRT for locally advanced gastric cancer.
|
| Publish Date |
2014-01-26 20:08 |
| Citation |
Wang X, Jin J, Li YX, Ren H, Fang H, Wang SL, Liu YP, Wang WH, Yu ZH, Song YW, Liu XF. Phase Ⅰ study of postoperative radiotherapy combined with capecitabine for gastric cancer. World J Gastroenterol 2014; 20(4): 1067-1073 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i4/1067.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i4.1067 |
