| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Decreased expression of the long non-coding RNA HOXD-AS2 promotes gastric cancer progression by targeting HOXD8 and activating PI3K/Akt signaling pathway
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Lin Yao, Peng-Cheng Ye, Wang Tan, Ya-Jun Luo, Wan-Ping Xiang, Zi-Lin Liu, Zhi-Ming Fu, Fei Lu, Ling-Han Tang and Jiang-Wei Xiao |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China (NSFC) |
30700773 |
| National Natural Science Foundation of China (NSFC) |
81070378 |
| National Natural Science Foundation of China (NSFC) |
81270561 |
| Sichuan Outstanding Youth Fund Project |
2015JQ0060 |
|
| Corresponding Author |
Jiang-Wei Xiao, MD, PhD, Postdoc, Professor, Surgeon, Surgical Oncologist, Teacher, Department of Gastrointestinal Surgery, Clinical Medical College and The First Affiliated Hospital of Chengdu Medical College, No. 278 Baoguang Road, Xindu District, Chengdu 610000, Sichuan Province, China. xiaojiangwei2018@163.com |
| Key Words |
Long non-coding RNA; Gastric cancer; HOXD-AS2; HOXD8; PI3K/Akt; Progression |
| Core Tip |
In this study we found that the expression of long non-coding RNA HOXD-AS2 is down-regulated in gastric cancer (GC) tissues and cells. The low expression of HOXD-AS2 was associated with lymph node metastasis and Tumor-Node-Metastasis stage in GC. Overexpression of HOXD-AS2 inhibits the progression of GC cells. Decreased expression of HOXD-AS2 promotes GC cells progression by targeting HOXD8 and activating the PI3K/Akt signalling pathway. HOXD-AS2 may be a novel diagnostic biomarker and effective therapeutic target for GC patients. |
| Publish Date |
2020-11-12 03:59 |
| Citation |
Yao L, Ye PC, Tan W, Luo YJ, Xiang WP, Liu ZL, Fu ZM, Lu F, Tang LH, Xiao JW. Decreased expression of the long non-coding RNA HOXD-AS2 promotes gastric cancer progression by targeting HOXD8 and activating PI3K/Akt signaling pathway. World J Gastrointest Oncol 2020; 12(11): 1237-1254 |
| URL |
https://www.wjgnet.com/1948-5204/full/v12/i11/1237.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v12.i11.1237 |
