Publication Name	World Journal of Gastroenterology
Manuscript ID	5852
Country	United States

Received	2013-09-28 15:59
Peer-Review Started	2013-09-29 12:28
To Make the First Decision	2013-11-21 20:58
Return for Revision	2013-11-22 09:34
Revised	2013-11-26 03:26
Second Decision	2014-01-06 18:23
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-01-06 18:56
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-01-20 09:55
Publish the Manuscript Online	2014-02-20 19:40

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Novel methylxanthine derivative-mediated anti-inflammatory effects in inflammatory bowel disease
Manuscript Source	Invited Manuscript
All Author List	In-Ah Lee, Alan Kamba, Daren Low and Emiko Mizoguchi
Funding Agency and Grant Number	Funding Agency Grant Number National Institutes of Health DK80070 Broad Medical Foundation to Mizoguchi E National Research Foundation of Korea to Lee IA Singapore A*STAR Graduate Academy to Low D
Corresponding Author	Emiko Mizoguchi, MD, PhD, Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, GRJ 825D, 55 Fruit Street, Boston, MA 02114, United States. emizoguchi@mgh.harvard.edu
Key Words	Adherent-invasive Escherichia coli; Chitinase 3-like 1; Chitinase inhibitors; Intestinal epithelial cells; Host-microbial interactions; Inflammatory bowel disease
Core Tip	The involvement of family 18 chitinases in the pathogenesis of inflammatory bowel disease has been increasing characterized. The discovery of methylxanthine derivatives as an effective inhibitor of family 18 chitinases provides a good tool to control the pathogenic effects of these proteins. This review discusses the underlying inhibitory mechanisms of the different methylxanthine derivatives and how these compounds have been shown to be effective in the amelioration of animal colitis models. As such, this mode of application can be extended to target other family 18 chitinases associated disorders such as asthma.
Publish Date	2014-02-20 19:40
Citation	Lee IA, Kamba A, Low D, Mizoguchi E. Novel methylxanthine derivative-mediated anti-inflammatory effects in inflammatory bowel disease. World J Gastroenterol 2014; 20(5): 1127-1138
URL	http://www.wjgnet.com/1007-9327/full/v20/i5/1127.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i5.1127

Full Article (PDF)	WJG-20-1127.pdf
Full Article (Word)	WJG-20-1127.doc
Manuscript File	5852-Review.doc
Answering Reviewers	5852-Answering reviewers.pdf
Copyright License Agreement	5852-Copyright assignment.pdf
Peer-review Report	5852-Peer reviews.pdf
Scientific Editor Work List	5852-Scientific editor work list.doc