Publication Name	World Journal of Gastroenterology
Manuscript ID	5853
Country	Japan

Received	2013-09-28 16:03
Peer-Review Started	2013-09-29 13:51
To Make the First Decision	2013-12-03 19:11
Return for Revision	2013-12-13 15:45
Revised	2014-01-29 15:24
Second Decision	2014-04-03 10:12
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-04-03 12:25
Articles in Press	2014-05-23 10:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-07-07 09:54
Publish the Manuscript Online	2014-07-21 17:17

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Molecular biomarkers for the detection of metastatic colorectal cancer cells
Manuscript Source	Invited Manuscript
All Author List	Hidenori Kamiyama, Hiroshi Noda, Fumio Konishi and Toshiki Rikiyama
Funding Agency and Grant Number
Corresponding Author	Hiroshi Noda, MD, Department of Surgery, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma-cho, Omiya-ku, Saitama 330-8503, Japan. noda164@hotmail.co.jp
Key Words	Molecular biomarker; Metastatic colorectal cancer cell; Circulating tumor cell; Disseminated tumor cell; Peritoneal lavage fluid; Colorectal cancer
Core Tip	We focus on methods of the detection of molecular changes in metastatic colorectal cancer cells, and describe the characteristics for the methods, such as DNA methylation, mRNA, microRNA, immunomagnetic separation, protein and cancer-associated mutations. Moreover, we review the clinical significance according to the type of samples, such as blood, lymph node, bone marrow and peritoneal lavage fluid. At present, it is difficult to conclude that one specific molecular marker is superior to others. Comparative analyses are recommended to assess the prognostic impact of molecular analyses in the same patient and determine the biomarkers that provide the most accurate prognostic information.
Publish Date	2014-07-21 17:17
Citation	Kamiyama H, Noda H, Konishi F, Rikiyama T. Molecular biomarkers for the detection of metastatic colorectal cancer cells. World J Gastroenterol 2014; 20(27): 8928-8938
URL	http://www.wjgnet.com/1007-9327/full/v20/i27/8928.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i27.8928

Full Article (PDF)	WJG-20-8928.pdf
Full Article (Word)	WJG-20-8928.doc
Manuscript File	5853-Review.doc
Answering Reviewers	5853-Answering reviewers.pdf
Copyright License Agreement	5853-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	5853-Language certificate.pdf
Peer-review Report	5853-Peer reviews.pdf
Scientific Editor Work List	5853-Scientific editor work list.doc