Publication Name	World Journal of Gastroenterology
Manuscript ID	5856
Country	Italy

Received	2013-09-28 16:28
Peer-Review Started	2013-09-29 14:01
First Decision by Editorial Office Director
Return for Revision	2013-10-23 11:20
Revised	2014-01-11 23:04
Publication Fee Transferred
Second Decision by Editor	2014-04-29 12:20
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-04-29 14:21
Articles in Press	2014-05-23 11:04
Edit the Manuscript by Language Editor	2014-05-14 20:24
Typeset the Manuscript	2014-07-14 09:33
Publish the Manuscript Online	2014-07-26 13:36

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Treatment of rectal cancer by transanal endoscopic microsurgery: Experience with 425 patients
Manuscript Source	Invited Manuscript
All Author List	Mario Guerrieri, Rosaria Gesuita, Roberto Ghiselli, Giovanni Lezoche, Andrea Budassi and Maddalena Baldarelli
Funding Agency and Grant Number
Corresponding Author	Mario Guerrieri, MD, Department of General Surgery, Università Politecnica delle Marche, Via Conca 71, 60126 Ancona, Italy. guerrieri.m@libero.it
Key Words	Rectal cancer; Transanal endoscopic microsurgery; Chemoradiotherapy; Local excision; Downstaging
Core Tip	The gold standard treatment for locally advanced rectal cancer, major surgery, is associated with a high incidence of definitive stoma. In the 1980s, Buess pioneered the removal of rectal lesions with full-thickness excision by transanal endoscopic microsurgery (TEM). It was subsequently demonstrated that T1-N0 lesions can be treated by TEM alone. However, neoadjuvant chemoradiotherapy can downstage T2-T3-N0 lesions and even elicit a complete response. In our experience, the local recurrence and survival rates of selected patients with local-advanced rectal cancer and no nodal involvement treated with neoadjuvant therapy and TEM do not differ significantly from patients treated by major surgery.
Publish Date	2014-07-26 13:36
Citation	Guerrieri M, Gesuita R, Ghiselli R, Lezoche G, Budassi A, Baldarelli M. Treatment of rectal cancer by transanal endoscopic microsurgery: Experience with 425 patients. World J Gastroenterol 2014; 20(28): 9556-9563
URL	http://www.wjgnet.com/1007-9327/full/v20/i28/9556.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i28.9556

Full Article (PDF)	WJG-20-9556.pdf
Full Article (Word)	WJG-20-9556.doc
Manuscript File	5856-Review.doc
Answering Reviewers	5856-Answering reviewers.pdf
Copyright License Agreement	5856-Copyright assignment.pdf
Peer-review Report	5856-Peer reviews.pdf
Scientific Editor Work List	5856-Scientific editor work list.pdf