Publication Name	World Journal of Hepatology
Manuscript ID	58594
Country	Japan

Received	2020-07-28 22:05
Peer-Review Started	2020-07-28 22:06
To Make the First Decision
Return for Revision	2020-09-17 17:14
Revised	2020-09-29 16:01
Second Decision	2020-10-21 12:53
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2020-10-21 16:48
Articles in Press	2020-10-21 16:48
Publication Fee Transferred
Edit the Manuscript by Language Editor	2020-10-31 23:41
Typeset the Manuscript	2020-12-10 02:45
Publish the Manuscript Online	2020-12-18 05:58

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Surgery
Manuscript Type	Case Report
Article Title	Successful hepatic resection for recurrent hepatocellular carcinoma after lenvatinib treatment: A case report
Manuscript Source	Invited Manuscript
All Author List	Hideki Yokoo, Hiroyuki Takahashi, Masahiro Hagiwara, Hiroyoshi Iwata, Koji Imai, Yoshinori Saito, Naoto Matsuno and Hiroyuki Furukawa
ORCID	Author(s) ORCID Number Hideki Yokoo http://orcid.org/0000-0002-6203-8528 Hiroyuki Takahashi http://orcid.org/0000-0003-2876-5964 Masahiro Hagiwara http://orcid.org/0000-0002-2589-3955 Hiroyoshi Iwata http://orcid.org/0000-0002-3970-0827 Koji Imai http://orcid.org/0000-0001-9318-1450 Yoshinori Saito http://orcid.org/0000-0002-9861-0442 Naoto Matsuno http://orcid.org/0000-0001-5186-7331 Hiroyuki Furukawa http://orcid.org/0000-0003-3559-4155
Funding Agency and Grant Number
Corresponding Author	Hideki Yokoo, MD, PhD, Associate Professor, Division of Hepato-Biliary-Pancreatic Surgery and Transplant Surgery, Department of Surgery, Asahikawa Medical University, 2-1 Midorigaoka-Higashi, Asahikawa 078-8510, Hokkaido, Japan. hidekiyokoo@asahikawa-med.ac.jp
Key Words	Conversion to surgery; Lenvatinib; Recurrent hepatocellular carcinoma; Case report; Neoadjuvant therapy; Molecular targeted therapy
Core Tip	Lenvatinib was shown to be noninferior to sorafenib for unresectable hepatocellular carcinoma (HCC), and tumor shrinkage was observed in ~40% of cases. We report a case of intrahepatic HCC recurrence with rapid growth and sternal bone metastases after initial resection of HCC, in which conversion to second surgery was successfully achieved after lenvatinib administration induced tumor shrinkage. Regarding histopathological findings, 80% of the tumor was necrotic and the resected margin of the liver surface showed no cancer component. Tumor marker PIVKA-II decreased to the normal range after surgery. Because the patient had bone metastases, multidisciplinary therapy, postoperative radiation therapy, and lenvatinib administration were performed, and the patient remains alive at 1 year postoperatively. In this case, lenvatinib induced a partial response for rapid growth of recurrent HCC with bone metastases, and conversion to surgery was successfully achieved for the purpose of controlling the intrahepatic lesion for the first time.
Publish Date	2020-12-18 05:58
Citation	Yokoo H, Takahashi H, Hagiwara M, Iwata H, Imai K, Saito Y, Matsuno N, Furukawa H. Successful hepatic resection for recurrent hepatocellular carcinoma after lenvatinib treatment: A case report. World J Hepatol 2020; 12(12): 1349-1357
URL	https://www.wjgnet.com/1948-5182/full/v12/i12/1349.htm
DOI	https://dx.doi.org/10.4254/wjh.v12.i12.1349

Full Article (PDF)	WJH-12-1349.pdf
Full Article (Word)	WJH-12-1349.docx
CARE Checklist–2016	58594-CARE-Checklist–2016-revision.pdf
Manuscript File	58594-Review-Filipodia.docx
Answering Reviewers	58594-Answering reviewers.pdf
Audio Core Tip	58594-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	58594-Conflict-of-interest statement.pdf
Copyright License Agreement	58594-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	58594-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate	58594-Language certificate.pdf
Peer-review Report	58594-Peer-review(s).pdf
Scientific Misconduct Check	58594-Scientific misconduct check.pdf
Scientific Editor Work List	58594-Scientific editor work list.pdf
CrossCheck Report	58594-CrossCheck report.pdf