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10/28/2020 8:26:09 AM | Browse: 351 | Download: 681
Publication Name World Journal of Gastroenterology
Manuscript ID 58647
Country/Territory Australia
2020-07-31 04:13
Peer-Review Started
2020-07-31 04:13
To Make the First Decision
Return for Revision
2020-08-22 18:26
2020-08-28 06:22
Second Decision
2020-09-16 12:30
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-09-17 04:50
Articles in Press
2020-09-17 04:50
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2020-10-27 01:43
Publish the Manuscript Online
2020-10-28 08:26
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Review
Article Title Cirrhotic portal hypertension: From pathophysiology to novel therapeutics
Manuscript Source Invited Manuscript
All Author List Lakmie S Gunarathne, Harinda Rajapaksha, Nicholas Shackel, Peter W Angus and Chandana B Herath
Author(s) ORCID Number
Lakmie S Gunarathne http://orcid.org/0000-0001-8505-2317
Harinda Rajapaksha http://orcid.org/0000-0001-7521-0991
Nicholas Shackel http://orcid.org/0000-0001-6441-7145
Peter W Angus http://orcid.org/0000-0001-8505-2317
Chandana B Herath http://orcid.org/0000-0001-9151-8531
Funding Agency and Grant Number
Funding Agency Grant Number
National Health and Medical Research Council (NHMRC) of Australia Project Grants APP1124125
Corresponding Author Chandana B Herath, PhD, Senior Lecturer, South Western Sydney Clinical School, Faculty of Medicine, University of New South Wales, Ingham Institute for Applied Medical Research, 1 Campbell Street, Liverpool 2170, NSW, Australia. c.herath@unsw.edu.au
Key Words Portal hypertension; Cirrhosis; Intrahepatic vascular resistance; Hyperdynamic circulatory state; Splanchnic vasodilatation; Portal blood flow
Core Tip Cirrhosis is a major cause of death and affects over 300 million people worldwide. Portal hypertension is a life-threatening complication of cirrhosis, characterized by splanchnic vasodilatation, the formation of varices and variceal bleeding, which account for much of the mortality and morbidity in cirrhotic patients. Current ‘gold standard’ clinical treatment is non-selective b-blockers; however, their efficacy and tolerability are suboptimal. Recent findings from the author’s laboratory and others suggest that the alternate renin angiotensin system is a potential target to design and develop novel therapeutics to inhibit splanchnic vasodilatation in cirrhotic portal hypertension.
Publish Date 2020-10-28 08:26
Citation Gunarathne LS, Rajapaksha H, Shackel N, Angus PW, Herath CB. Cirrhotic portal hypertension: From pathophysiology to novel therapeutics. World J Gastroenterol 2020; 26(40): 6111-6140
URL https://www.wjgnet.com/1007-9327/full/v26/i40/6111.htm
DOI https://dx.doi.org/10.3748/wjg.v26.i40.6111
Full Article (PDF) WJG-26-6111.pdf
Full Article (Word) WJG-26-6111.docx
Manuscript File 58647-Review.docx
Answering Reviewers 58647-Answering reviewers.pdf
Audio Core Tip 58647-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 58647-Conflict-of-interest statement.pdf
Copyright License Agreement 58647-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 58647-Grant application form(s).pdf
Peer-review Report 58647-Peer-review(s).pdf
Scientific Misconduct Check 58647-Bing-Yan JP-1.png
Scientific Misconduct Check 58647-Bing-Chen XF-2.png
Scientific Misconduct Check 58647-Scientific misconduct check.pdf
Scientific Editor Work List 58647-Scientific editor work list.pdf