Publication Name	World Journal of Clinical Oncology
Manuscript ID	58658
Country	Chile

Received	2020-07-31 16:48
Peer-Review Started	2020-07-31 16:49
To Make the First Decision
Return for Revision	2020-09-17 16:56
Revised	2020-10-01 15:01
Second Decision	2020-10-20 12:22
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2020-10-20 21:44
Articles in Press	2020-10-20 21:44
Publication Fee Transferred
Edit the Manuscript by Language Editor	2020-11-02 08:15
Typeset the Manuscript	2020-12-16 07:06
Publish the Manuscript Online	2020-12-18 12:27

ISSN	2218-4333 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Editorial
Article Title	New standard in locally advanced rectal cancer
Manuscript Source	Invited Manuscript
All Author List	Sebastián Solé, Ramón Baeza, Carolina Gabler and Felipe Couñago
ORCID	Author(s) ORCID Number Sebastián Solé http://orcid.org/0000-0002-9291-2319 Ramón Baeza http://orcid.org/0000-0001-7142-2567 Carolina Gabler http://orcid.org/0000-0002-0800-3746 Felipe Couñago http://orcid.org/0000-0001-7233-0234
Funding Agency and Grant Number
Corresponding Author	Sebastián Solé, MD, Director, Director, Department of Radiation Oncology, IRAM Clinic, NA, Santiago 7630294, Chile. sebasole@gmail.com
Key Words	Locally advanced rectal cancer; Total neoadjuvant treatment; Short-course radiotherapy; Oxaliplatin; Neoadjuvant chemoradiotherapy; Long-course radiotherapy
Core Tip	In this review we intend to ascertain the optimal neoadjuvant therapy in patients with locally advanced rectal cancer. In terms of chemotherapy (CT) it has recently been demonstrated that oxaliplatin based CT after short-course radiotherapy presents greater pathological response and lower acute toxicity than concomitant chemoradiotherapy. Studies presented during 2020 have also shown this benefit, as well as better disease and metastasis-free survival. Our review suggests that probably total neoadjuvant treatment should be the new standard treatment for these patients. Though we will have to wait for the full text publications of these studies to confirm this statement.
Publish Date	2020-12-18 12:27
Citation	Solé S, Baeza R, Gabler C, Couñago F. New standard in locally advanced rectal cancer. World J Clin Oncol 2020; 11(12): 990-995
URL	https://www.wjgnet.com/2218-4333/full/v11/i12/990.htm
DOI	https://dx.doi.org/10.5306/wjco.v11.i12.990

Full Article (PDF)	WJCO-11-990.pdf
Full Article (Word)	WJCO-11-990.docx
Manuscript File	58658_Auto_Edited-Webster J.docx
Answering Reviewers	58658-Answering reviewers.pdf
Audio Core Tip	58658-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	58658-Conflict-of-interest statement.pdf
Copyright License Agreement	58658-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	58658-Language certificate.pdf
Peer-review Report	58658-Peer-review(s).pdf
Scientific Misconduct Check	58658-Scientific misconduct check.pdf
Scientific Editor Work List	58658-Scientific editor work list.pdf
CrossCheck Report	58658-CrossCheck report.pdf