Publication Name	World Journal of Gastroenterology
Manuscript ID	5870
Country	Italy

Received	2013-10-07 16:15
Peer-Review Started	2013-10-08 09:33
To Make the First Decision	2013-12-16 17:06
Return for Revision	2013-12-17 15:39
Revised
Second Decision	2014-04-03 10:12
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-04-03 12:26
Articles in Press	2014-05-23 12:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-06-02 13:58
Publish the Manuscript Online	2014-06-21 13:56

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Pathogenesis and significance of hepatitis C virus steatosis: An update on survival strategy of a successful pathogen
Manuscript Source	Invited Manuscript
All Author List	Amedeo Lonardo, Luigi Elio Adinolfi, Luciano Restivo, Stefano Ballestri, Dante Romagnoli, Enrica Baldelli, Fabio Nascimbeni and Paola Loria
Funding Agency and Grant Number
Corresponding Author	Amedeo Lonardo, MD, Division of Internal Medicine, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Via Giardini 1355, 41126 Modena, Italy. a.lonardo@libero.it
Key Words	Atherosclerosis; Fibrosis; Hepatitis C-associated dysmetabolic syndrome; Hepatocellular carcinoma; Steatohepatitis; Sustained virological response; Hepatitis C virus
Core Tip	Hepatitis C virus (HCV) steatosis occurs in the setting of multiple abnormalities collectively referred to as “hepatitis C-associated dysmetabolic syndrome”. General, nonalcoholic fatty liver disease-like, mechanisms of steatogenesis are shared by all HCV genotypes. However, genotype 3 seemingly amplifies such steatogenic molecular mechanisms. HCV steatosis has a remarkable clinical impact in accelerating fibrogenesis; impairing treatment response to interferons and ribavirin; and favouring the development of hepatocellular carcinoma and atherosclerosis. In conclusion, steatosis fulfills all expected requirements necessary to perpetuate the HCV life cycle and is associated with HCV infection by necessity rather than by chance.
Publish Date	2014-06-21 13:56
Citation	Lonardo A, Adinolfi LE, Restivo L, Ballestri S, Romagnoli D, Baldelli E, Nascimbeni F, Loria P. Pathogenesis and significance of hepatitis C virus steatosis: An update on survival strategy of a successful pathogen. World J Gastroenterol 2014; 20(23): 7089-7103
URL	http://www.wjgnet.com/1007-9327/full/v20/i23/7089.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i23.7089

Full Article (PDF)	WJG-20-7089.pdf
Full Article (Word)	WJG-20-7089.doc
Manuscript File	5870-Review.doc
Answering Reviewers	5870-Answering reviewers.pdf
Copyright License Agreement	5870-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	5870-Language certificate.pdf
Peer-review Report	5870-Peer reviews.pdf
Scientific Editor Work List	5870-Scientific editor work list.doc