Publication Name	World Journal of Gastroenterology
Manuscript ID	5874
Country	China

Received	2013-09-28 17:41
Peer-Review Started	2013-09-29 14:46
To Make the First Decision	2013-10-14 21:07
Return for Revision	2013-10-17 09:57
Revised	2013-11-01 16:42
Second Decision	2013-11-13 12:04
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-11-13 15:22
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-11-21 17:51
Typeset the Manuscript	2013-12-10 10:08
Publish the Manuscript Online	2013-12-18 10:39

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Role of Helicobacter pylori virulence factor cytotoxin-associated gene A in gastric mucosa-associated lymphoid tissue lymphoma
Manuscript Source	Invited Manuscript
All Author List	Hong-Ping Wang, Yong-Liang Zhu and Wei Shao
Funding Agency and Grant Number	Funding Agency Grant Number Foundation of Scientific Technology Bureau of Zhejiang Province, China 2010C33118
Corresponding Author	Wei Shao, MD, Department of Gastroenterology, People's Hospital of Putuo District, 24F Xincheng District, Zhoushan 316000, Zhejiang Province, China. 667318_won@sina.com
Key Words	Helicobacter pylori; Cytotoxin-associated gene A; Gastric mucosa-associated lymphoid tissue lymphoma; Lymphomagenesis; Molecular mechanism
Core Tip	Cytotoxin-associated gene A (CagA) protein encoded by cag pathogenicity island of Helicobacter pylori is a bacterium-derived oncoprotein and is strongly associated with the gastric mucosa-associated lymphoid tissue (MALT) lymphoma. After being translocated into B cells via type 鈪?secretion system in ATP-dependent manner, CagA deregulates several pathways in both tyrosine phosphorylation-dependent and -independent manners, and thereby promotes lymphomagenesis. Two important proteins, p53 and protein tyrosine phosphatases-2, are involved in the malignant transformation induced by CagA. In addition, mucosal inflammation is the foundational mechanism underlying the occurrence and development of gastric MALT lymphoma. However, the exact mechanism by which CagA promotes oncogenesis needs further clarification.
Publish Date	2013-12-18 10:39
Citation	Wang HP, Zhu YL, Shao W. Role of Helicobacter pylori virulence factor cytotoxin-associated gene A in gastric mucosa-associated lymphoid tissue lymphoma. World J Gastroenterol 2013; 19(45): 8219-8226
URL	http://www.wjgnet.com/1007-9327/full/v19/i45/8219.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i45.8219

Full Article (PDF)	WJG-19-8219.pdf
Manuscript File	5874-Review.doc
Answering Reviewers	5874-Answering reviewers.pdf
Copyright License Agreement	5874-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	5874-Language certificate.pdf
Peer-review Report	5874-Peer reviews.pdf
Scientific Editor Work List	5874-Scientific editor work list.doc