Publication Name	World Journal of Gastroenterology
Manuscript ID	5888
Country	Japan

Received	2013-10-03 20:29
Peer-Review Started	2013-10-04 16:31
To Make the First Decision	2013-12-16 17:06
Return for Revision	2013-12-17 15:29
Revised	2013-12-20 17:40
Second Decision	2014-04-03 10:13
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-04-03 12:26
Articles in Press	2014-05-23 10:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-07-07 11:51
Publish the Manuscript Online	2014-07-21 17:17

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Chemoprevention of colorectal cancer by targeting obesity-related metabolic abnormalities
Manuscript Source	Invited Manuscript
All Author List	Yohei Shirakami, Masahito Shimizu, Masaya Kubota, Hiroshi Araki, Takuji Tanaka, Hisataka Moriwaki and Mitsuru Seishima
Funding Agency and Grant Number
Corresponding Author	Masahito Shimizu, M.D., Ph.D. Department of Gastroenterology/Internal Medicine, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan Phone: +81-(58) 230-6313; Fax: +81-(58) 230-6310; E-mail: shimim-gif@umin.ac.jp
Key Words	Colorectal cancer; Obesity; Green tea catechin; Branched-chain amino acid; Chemoprevention
Core Tip	Obesity and its related metabolic disorders increase the risk of colorectal cancer (CRC). Many studies using obese animal models have been conducted to investigate the chemoprevention of CRC using pharmaceutical or nutritional interventions. Lipid-lowering and anti-hypertensive medicines suppress the development of colonic preneoplastic lesions in obese mice. Green tea catechins improve metabolic disorders and prevent the development of CRC. The administration of branched-chain amino acids may be effective for suppressing obesity-related CRC. This review summarizes recent evidence that suggests that targeting metabolic alterations may be an effective strategy for preventing the development of CRC in obese individuals.
Publish Date	2014-07-21 17:17
Citation	Shirakami Y, Shimizu M, Kubota M, Araki H, Tanaka T, Moriwaki H, Seishima M. Chemoprevention of colorectal cancer by targeting obesity-related metabolic abnormalities. World J Gastroenterol 2014; 20(27): 8939-8946
URL	http://www.wjgnet.com/1007-9327/full/v20/i27/8939.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i27.8939

Full Article (PDF)	WJG-20-8939.pdf
Full Article (Word)	WJG-20-8939.doc
Manuscript File	5888-Review.docx
Answering Reviewers	5888-Ansewering reviewers.pdf
Copyright License Agreement	5888-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	5888-Language certificate.pdf
Peer-review Report	5888-Peer reviews.pdf
Scientific Editor Work List	5888-Scientific editor work list.doc