Publication Name	World Journal of Gastroenterology
Manuscript ID	5891
Country	Taiwan

Received	2013-09-28 18:48
Peer-Review Started	2013-09-29 15:36
To Make the First Decision	2013-10-14 21:06
Return for Revision	2013-10-17 10:24
Revised	2013-12-25 22:45
Second Decision	2014-02-20 15:31
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-02-20 15:57
Articles in Press	2014-05-23 12:03
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-04-22 11:30
Typeset the Manuscript	2014-05-29 18:16
Publish the Manuscript Online	2014-06-16 16:19

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Input of microenvironmental regulation on colorectal cancer: Role of the CCN family
Manuscript Source	Invited Manuscript
All Author List	Cheng-Chi Chang, Been-Ren Lin, Tai-Sheng Wu, Yung-Ming Jeng and Min-Liang Kuo
Funding Agency and Grant Number
Corresponding Author	Min-Liang Kuo, Professor, Institute of Biochemical Sciences, College of Life Science, National Taiwan University, Section 1, Jen-Ai Road No. 1, Taipei 100, Taiwan. kuominliang@ntu.edu.tw
Key Words	Microenvironment; Colorectal cancer; CCN proteins; Tumorigenicity; Cancer progression
Core Tip	Colorectal cancer (CRC) is a major health problem causing significant morbidity and mortality. Many studies have revealed that CCN members, such as CCN1, CCN2, CCN3, Wnt-induced secreted protein (WISP)-1, WISP-2, and WISP-3, are dysregulated in CRC, which implied potential diagnostic markers or therapeutic targets clinically. In this review, we summarize the research findings on the role of CCN family proteins in CRC initiation, development, and progression, highlighting their potential for diagnosis, prognosis, and therapeutic application, as well as discussing future perspectives.
Publish Date	2014-06-16 16:19
Citation	Chang CC, Lin BR, Wu TS, Jeng YM, Kuo ML. Input of microenvironmental regulation on colorectal cancer: Role of the CCN family. World J Gastroenterol 2014; 20(22): 6826-6831
URL	http://www.wjgnet.com/1007-9327/full/v20/i22/6826.htm
DOI	10.3748/wjg.v20.i22.6826

Full Article (PDF)	WJG-20-6826.pdf
Full Article (Word)	WJG-20-6826.doc
Manuscript File	5891-Review.doc
Answering Reviewers	5891-Answering reviewers.pdf
Copyright License Agreement	5891-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	5891-Language certificate.pdf
Peer-review Report	5891-Peer reviews.pdf
Scientific Editor Work List	5891-Scientific editor work list.doc