Publication Name	World Journal of Gastroenterology
Manuscript ID	5895
Country	Italy

Received	2013-09-28 18:54
Peer-Review Started	2013-09-29 15:52
To Make the First Decision	2013-11-12 19:15
Return for Revision	2013-11-15 15:15
Revised	2013-12-05 22:42
Second Decision	2014-04-23 09:01
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-04-23 10:04
Articles in Press	2014-05-23 10:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-07-18 15:25
Publish the Manuscript Online	2014-08-07 10:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Inflammatory pathways in the early steps of colorectal cancer development
Manuscript Source	Invited Manuscript
All Author List	Francesco Mariani, Paola Sena and Luca Roncucci
Funding Agency and Grant Number	Funding Agency Grant Number Fondazione Umberto Veronesi (FUV) Associazione Ricerca Tumori Intestinali (ARTI) of Modena
Corresponding Author	Luca Roncucci, MD, PhD, Department of Diagnostic, Clinical and Public Health Medicine, University of Modena and Reggio Emilia, Via Università, 4, 41124 Modena, Italy. luca.roncucci@unimore.it
Key Words	Myeloperoxidase; Colorectal carcinogenesis; Inflammation; Aberrant crypt foci; Autophagy; Hypoxia; Apoptosis
Core Tip	This paper examines the most important inflammatory pathways involved in the very early steps of colorectal carcinogenesis. In particular, it emphasizes the role played by cells of the immune system and key proteins, like cyclooxygenases, resistins, hypoxia-inducible factor 1, nuclear factor E2-related factor 2, and sirtuins, in fostering changes in mechanisms, like cell proliferation, DNA damage, apoptosis and autophagy, anaerobial metabolism and tissue remodeling, considered central for colorectal cancer development.
Publish Date	2014-08-07 10:34
Citation	Mariani F, Sena P, Roncucci L. Inflammatory pathways in the early steps of colorectal cancer development. World J Gastroenterol 2014; 20(29): 9716-9731
URL	http://www.wjgnet.com/1007-9327/full/v20/i29/9716.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i29.9716

Full Article (PDF)	WJG-20-9716.pdf
Full Article (Word)	WJG-20-9716.doc
Manuscript File	5895-Review.doc
Answering Reviewers	5895-Answering reviewers.pdf
Copyright License Agreement	5895-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	5895-Language certificate.pdf
Peer-review Report	5895-Peer reviews.pdf
Scientific Editor Work List	5895-Scientific editor work list.doc