Publication Name	World Journal of Gastroenterology
Manuscript ID	5897
Country	Germany

Received	2013-09-28 19:01
Peer-Review Started	2013-09-29 16:16
To Make the First Decision	2013-10-14 21:06
Return for Revision	2013-10-17 10:47
Revised	2013-11-08 07:14
Second Decision	2013-12-13 14:02
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-12-13 14:57
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-01-09 18:03
Publish the Manuscript Online	2014-02-20 19:40

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Intestinal barrier in inflammatory bowel disease
Manuscript Source	Invited Manuscript
All Author List	Lena Antoni, Sabine Nuding, Jan Wehkamp and Eduard F Stange
Funding Agency and Grant Number	Funding Agency Grant Number Robert Bosch Foundation, Stuttgart, Germany
Corresponding Author	Eduard F Stange, MD, Department of Internal Medicine I, Robert-Bosch-Hospital, Auerbachstr 110, D-70376 Stuttgart, Germany. eduard.stange@rbk.de
Key Words	Intestinal barrier; Antimicrobial peptide; Mucus layer; Inflammatory bowel disease; Crohn’s disease; Ulcerative colitis; Goblet cell; Paneth cell
Core Tip	An efficient intestinal mucosal barrier is critical for protection against invading microorganisms, therefore impairments in this system have serious adverse effects on health. In patients suffering from the inflammatory bowel diseases Crohn’s disease and ulcerative colitis, the intestinal barrier function is compromised at different levels including, amongst others, a defective production of antimicrobial peptides, alterations of the mucus layer and defects in the process of autophagy. In this article, we outline important components of the healthy intestinal mucosal barrier and review their disturbances in inflammatory bowel disease.
Publish Date	2014-02-20 19:40
Citation	Antoni L, Nuding S, Wehkamp J, Stange EF. Intestinal barrier in inflammatory bowel disease. World J Gastroenterol 2014; 20(5): 1165-1179
URL	http://www.wjgnet.com/1007-9327/full/v20/i5/1165.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i5.1165

Full Article (PDF)	WJG-20-1165.pdf
Full Article (Word)	WJG-20-1165.doc
Manuscript File	5897-Review.doc
Answering Reviewers	5897-Answering reviewers.pdf
Copyright License Agreement	5897-Copyright assignment.pdf
Peer-review Report	5897-Peer reviews.pdf
Scientific Editor Work List	5897-Scientific editor work list.doc