| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Nomograms and risk score models for predicting survival in rectal cancer patients with neoadjuvant therapy
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Fang-Ze Wei, Shi-Wen Mei, Jia-Nan Chen, Zhi-Jie Wang, Hai-Yu Shen, Juan Li, Fu-Qiang Zhao, Zheng Liu and Qian Liu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Key Research and Development Plan "Research on Prevention and Control of Major Chronic Noncommunicable Diseases" |
2019YFC1315705 |
| Medicine and Health Technology Innovation Project of the Chinese Academy of Medical Sciences |
2017-12M-1-006 |
|
| Corresponding Author |
Qian Liu, MD, Chief Doctor, Professor, Surgeon, Department of Colorectal Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China. fcwpumch@163.com |
| Key Words |
Neoadjuvant therapy; Rectal cancer; Nomogram; Overall survival; Disease-free survival; Risk factor score prediction model |
| Core Tip |
The manuscript focusses on the risk factors after administration of neoadjuvant therapy for locally advanced rectal cancer. The study utilized the least absolute shrinkage and selection operator and Cox regression to select risk factors for overall survival and disease-free survival and explore their prognostic value. Based on the factors, we built two nomograms and two risk factor score prediction models to predict survival time. Then, we validated the nomograms by calibration and the concordance index, and the prediction model was validated with receiver operating characteristic curves. The risk factors included in the model and nomograms can influence survival and recurrence and provide direction for clinical doctors to improve patient survival. |
| Publish Date |
2020-11-13 06:52 |
| Citation |
Wei FZ, Shen HY, Mei SW, Chen JN, Wang ZJ, Zhao FQ, Li J, Liu Z, Liu Q. Nomograms and risk score models for predicting overall survival and disease-free survival in rectal cancer with neoadjuvant therapy. World J Gastroenterol 2020; 26(42): 6638-6657 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i42/6638.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i42.6638 |
