Publication Name	World Journal of Gastroenterology
Manuscript ID	5901
Country	Singapore

Received	2013-09-28 19:22
Peer-Review Started	2013-09-29 16:43
To Make the First Decision
Return for Revision
Revised	2013-12-06 11:31
Second Decision	2014-01-20 17:27
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-01-20 18:23
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-03-04 15:30
Publish the Manuscript Online	2014-03-18 14:14

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Virology
Manuscript Type	Topic Highlights
Article Title	Understanding the interaction of hepatitis C virus with host DEAD-box RNA helicases
Manuscript Source	Invited Manuscript
All Author List	Megha Haridas Upadya, Jude Juventus Aweya and Yee-Joo Tan
Funding Agency and Grant Number	Funding Agency Grant Number Ministry of Education of Singapore R-182-000-17170-11112
Corresponding Author	Yee-Joo Tan, Associate Professor, Department of Microbiology, Yong Loo Lin School of Medicine, National University Health System (NUHS), National University of Singapore, MD4A, 5 Science Drive 2, Singapore 117597, Singapore. yee_joo_tan@nuhs.edu.sg
Key Words	Hepatitis C virus; Chronic hepatitis C; Hepatitis C virus therapy; DEAD-box helicases; Host factors; Hepatocellular carcinoma
Core Tip	Alternative treatments to combat chronic hepatitis C include direct-acting antivirals targeting hepatitis C virus (HCV) enzymes and host targeting agents that interfere with host factors essential for the viral life cycle. Several members of a family of host proteins known as DEAD-box RNA helicases have been shown to modulate HCV replication. This review highlights their interaction with HCV and their role in viral replication. Since hepatocellular carcinoma (HCC) is a major cause of death among patients with chronic hepatitis C, the involvement of these DEAD-box RNA helicases in the development of HCC will also be discussed.
Publish Date	2014-03-18 14:14
Citation	Upadya MH, Aweya JJ, Tan YJ. Understanding the interaction of hepatitis C virus with host DEAD-box RNA helicases. World J Gastroenterol 2014; 20(11): 2913-2926
URL	http://www.wjgnet.com/1007-9327/full/v20/i11/2913.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i11.2913

Full Article (PDF)	WJG-20-2913.pdf
Full Article (Word)	WJG-20-2913.doc
Manuscript File	5901-Review.doc
Answering Reviewers	5901-Answering reviewers.pdf
Copyright License Agreement	5901-Copyright assignment.pdf
Peer-review Report	5901-Peer reviews.pdf
Scientific Editor Work List	5901-Scientific editor work list.doc