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Articles Published Processes
11/13/2020 6:52:32 AM | Browse: 710 | Download: 1281
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Received |
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2020-08-29 21:39 |
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Peer-Review Started |
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2020-08-29 21:39 |
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To Make the First Decision |
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Return for Revision |
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2020-09-12 04:12 |
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Revised |
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2020-09-24 16:54 |
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Second Decision |
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2020-10-13 12:32 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-10-20 04:16 |
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Articles in Press |
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2020-10-20 04:16 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-11-12 02:21 |
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Publish the Manuscript Online |
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2020-11-13 06:52 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
What could microRNA expression tell us more about colorectal serrated pathway carcinogenesis?
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Milena Peruhova, Monika Peshevska-Sekulovska, Boris Krastev, Gabriela Panayotova, Viktoriya Georgieva, Rossitza Konakchieva, Georgi Nikolaev and Tsvetelina Veselinova Velikova |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Tsvetelina Veselinova Velikova, MD, PhD, Assistant Professor, Research Scientist, Department of Clinical Immunology, University Hospital Lozenetz, Kozyak 1 Street, Sofia 1407, Bulgaria. tsvelikova@medfac.mu-sofia.bg |
| Key Words |
MicroRNA; Serrated pathway; Carcinogenesis; Colorectal carcinoma; Sessile serrated lesions; Adenocarcinoma |
| Core Tip |
In addition to the adenoma to carcinoma transition, colorectal carcinogenesis can also occur via the serrated pathway. In most serrated polyps, the pathway is believed to include the acquisition of a mutation in a gene that regulates mitogen-activated protein kinase (MAPK) pathway, disruptions to the Wnt signaling pathway and widespread methylation of CpG islands. Moreover, there are less data about different microRNAs (miRNAs) expression profiling in serrated adenomas with different grades of dysplasia. In contrast to the conventional colorectal carcinogenesis, the pivotal role of miRNAs and their relevant signaling pathways in the serrated pathway of carcinogenesis is still to be elucidated because of an insufficient number of studies conducted to clarify separate steps in the process. |
| Publish Date |
2020-11-13 06:52 |
| Citation |
Peruhova M, Peshevska-Sekulovska M, Krastev B, Panayotova G, Georgieva V, Konakchieva R, Nikolaev G, Velikova TV. What could microRNA expression tell us more about colorectal serrated pathway carcinogenesis? World J Gastroenterol 2020; 26(42): 6556-6571 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i42/6556.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i42.6556 |
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