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Articles Published Processes
2/1/2021 11:01:10 AM | Browse: 400 | Download: 622
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Received |
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2020-09-27 12:21 |
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Peer-Review Started |
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2020-09-27 12:21 |
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To Make the First Decision |
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Return for Revision |
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2020-12-12 18:36 |
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Revised |
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2020-12-22 11:35 |
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Second Decision |
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2021-01-05 02:50 |
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Accepted by Journal Editor-in-Chief |
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2021-01-06 04:01 |
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Accepted by Company Editor-in-Chief |
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2021-01-07 20:20 |
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Articles in Press |
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2021-01-07 20:20 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-01-28 07:10 |
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Publish the Manuscript Online |
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2021-02-01 11:01 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Clinical and Translational Research |
| Article Title |
Total neoadjuvant therapy vs standard therapy of locally advanced rectal cancer with high-risk factors for failure
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Mojca Tuta, Nina Boc, Erik Brecelj, Monika Peternel and Vaneja Velenik |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Vaneja Velenik, MD, PhD, Associate Professor, Division of Radiotherapy, Institute of Oncology, Zaloška cesta 2, Ljubljana 1000, Slovenia. vvelenik@onko-i.si |
| Key Words |
Locally advanced rectal cancer; Total neoadjuvant therapy; Pathological complete response; Neoadjuvant rectal cancer score |
| Core Tip |
Our data suggest that treatment of locally advanced rectal cancer (LARC) with high-risk factors for failure using total neoadjuvant therapy (TNT) is more effective than standard therapy, achieving a higher rate of pathological complete response, more favourable survival prognosis, higher proportion of T-and N-downstaging, shorter time to temporary stoma closure, better compliance, and lower toxicity grade 3-5 during systemic chemotherapy. The outcomes of TNT in patients with the most aggressive form of LARC are completely comparable to TNT in all patients with LARC. |
| Publish Date |
2021-02-01 11:01 |
| Citation |
Tuta M, Boc N, Brecelj E, Peternel M, Velenik V. Total neoadjuvant therapy vs standard therapy of locally advanced rectal cancer with high-risk factors for failure. World J Gastrointest Oncol 2021; 13(2): 119-130 |
| URL |
https://www.wjgnet.com/1948-5204/full/v13/i2/119.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v13.i2.119 |
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