Publication Name	World Journal of Gastroenterology
Manuscript ID	5909
Country	Germany

Received	2013-09-28 20:02
Peer-Review Started	2013-09-29 17:08
To Make the First Decision	2013-12-16 17:07
Return for Revision	2013-12-17 15:14
Revised	2014-01-06 22:31
Second Decision	2014-03-06 17:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-03-06 18:23
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-03-18 17:24
Publish the Manuscript Online	2014-04-04 15:11

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Mathematical & Computational Biology
Manuscript Type	Topic Highlights
Article Title	Computational biology approach to uncover hepatitis C virus helicase operation
Manuscript Source	Invited Manuscript
All Author List	Holger Flechsig
Funding Agency and Grant Number
Corresponding Author	Dr. Holger Flechsig, Department of Physical Chemistry, Fritz Haber Institute of the Max Planck Society, Faradayweg 4-6, 14195 Berlin, Germany. flechsig@fhi-berlin.mpg.de
Key Words	Hepatitis C virus; Viral replication; Helicase protein; Adenosine-triphosphate-induced operation; Conformational motions; Nucleic acid unzipping; Computational biology; Coarse-grained modelling; Elastic-network model
Core Tip	Proteins that are involved in the replication cycle of hepatitis C virus are relevant targets for antiviral therapies. Their dynamical properties, however, cannot be sufficiently studied in experiments yet. Alternatively, owing to the available power of modern computers, the mechanism by which they operate can be investigated in computer experiments using appropriate models. In this regard, considerable progress has now been achieved for the viral helicase protein and the obtained results, in combination with experimental data, have significantly improved our understanding of its activity.
Publish Date	2014-04-04 15:11
Citation	Flechsig H. Computational biology approach to uncover hepatitis C virus helicase operation. World J Gastroenterol 2014; 20(13): 3401-3409
URL	http://www.wjgnet.com/1007-9327/full/v20/i13/3401.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i13.3401

Full Article (PDF)	WJG-20-3401.pdf
Full Article (Word)	WJG-20-3401.doc
Manuscript File	5909-Review.docx
Answering Reviewers	5909-Answering reviewers.pdf
Copyright License Agreement	5909-Copyright assignment.pdf
Peer-review Report	5909-Peer reviews.pdf
Scientific Editor Work List	5909-Scientific editor work list.doc