2/25/2021 3:45:30 PM | Browse: 554 | Download: 1447
| Publication Name | World Journal of Hepatology |
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| Manuscript ID | 59138 |
| Country | France |
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| ISSN | 1948-5182 (online) |
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| Open Access | This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright | © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247 |
| Permissions | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207 |
| Publisher | Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website | http://www.wjgnet.com |
| Category | Gastroenterology & Hepatology | ||||||||||||||||||||
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| Manuscript Type | Basic Study | ||||||||||||||||||||
| Article Title | Adult human liver slice cultures: Modelling of liver fibrosis and evaluation of new anti-fibrotic drugs | ||||||||||||||||||||
| Manuscript Source | Invited Manuscript | ||||||||||||||||||||
| All Author List | Daria Kartasheva-Ebertz, Jesintha Gaston, Loriane Lair-Mehiri, Pierre-Philippe Massault, Olivier Scatton, Jean-Christophe Vaillant, Vladimir Alexei Morozov, Stanislas Pol and Sylvie Lagaye | ||||||||||||||||||||
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| Corresponding Author | Sylvie Lagaye, DSc, PhD, Senior Scientist, Institut Pasteur, Immunobiologie des Cellules Dendritiques, INSERM U1223, 25-28 rue du Dr Roux, Paris 75015, France. sylvie.lagaye@inserm.fr | ||||||||||||||||||||
| Key Words | Human liver fibrosis; Hepatitis C virus; Alcoholic liver disease; Nonalcoholic steatohepatitis; Ex vivo model; Drugs | ||||||||||||||||||||
| Core Tip | In the developed world, about 45% of deaths are due to fibroproliferative diseases. Liver fibrosis is frequently associated with viral infection (Hepatitis C virus and Hepatitis B virus infection), chronic inflammation and excessive alcohol consumption. Despite the availability of effective antiviral drugs, morbidity, and mortality related to viral hepatitis are still increasing. Moreover, the number of non-viral liver diseases such as nonalcoholic steatohepatitis, and alcoholic liver disease is steadily growing. Our studies provide the proof of concept that the three-dimensional ex vivo model of human liver slice culture can be used for the molecular investigation of fibrosis as well as to perform follow-up studies of new anti-fibrotic drugs and therapies for a 21-d period. | ||||||||||||||||||||
| Publish Date | 2021-02-25 15:45 | ||||||||||||||||||||
| Citation | Kartasheva-Ebertz D, Gaston J, Lair-Mehiri L, Massault PP, Scatton O, Vaillant JC, Morozov VA, Stanislas P, Lagaye S. Adult human liver slice cultures: Modelling of liver fibrosis and evaluation of new anti-fibrotic drugs. World J Hepatol 2021; 13(2): 187-217 | ||||||||||||||||||||
| URL | https://www.wjgnet.com/1948-5182/full/v13/i2/187.htm | ||||||||||||||||||||
| DOI | https://dx.doi.org/10.4254/wjh.v13.i2.187 |
| Full Article (PDF) | WJH-13-187.pdf |
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| Full Article (Word) | WJH-13-187.docx |
| Manuscript File | 59138_Auto_Edited.docx |
| Answering Reviewers | 59138-Answering reviewers.pdf |
| Audio Core Tip | 59138-Audio core tip.m4a |
| Biostatistics Review Certificate | 59138-Biostatistics statement.pdf |
| Conflict-of-Interest Disclosure Form | 59138-Conflict-of-interest statement.pdf |
| Copyright License Agreement | 59138-Copyright license agreement.pdf |
| Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) | 59138-Grant application form(s).pdf |
| Institutional Review Board Approval Form or Document | 59138-Institutional review board statement.pdf |
| Non-Native Speakers of English Editing Certificate | 59138-Language certificate.pdf |
| Peer-review Report | 59138-Peer-review(s).pdf |
| Scientific Misconduct Check | 59138-Scientific misconduct check.pdf |
| Scientific Editor Work List | 59138-Scientific editor work list.pdf |
| CrossCheck Report | 59138-CrossCheck report.pdf |