Publication Name	World Journal of Gastroenterology
Manuscript ID	5921
Country	Greece

Received	2013-09-28 20:45
Peer-Review Started	2013-09-30 10:51
To Make the First Decision	2013-10-22 16:28
Return for Revision	2013-10-23 12:36
Revised	2013-11-12 21:22
Second Decision	2014-01-06 18:32
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-01-06 18:51
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-03-12 13:38
Typeset the Manuscript	2014-03-19 12:13
Publish the Manuscript Online	2014-04-14 10:49

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Topic Highlights
Article Title	Natural history of hepatic metastases from colorectal cancer - pathobiological pathways with clinical significance
Manuscript Source	Invited Manuscript
All Author List	Konstantinos A Paschos, Ali W Majeed and Nigel C Bird
Funding Agency and Grant Number
Corresponding Author	Konstantinos A Paschos, MD, MSc, PhD, Department of Surgery, General Hospital of Drama, Terma Hippokratous Str., GR66100 Drama, Greece. kostaspaschos@yahoo.gr
Key Words	Colorectal cancer; Metastatic cascade; Liver metastasis; Liver sinusoids; Neovascularization
Core Tip	The multi-step process of colorectal hepatic metastases includes numerous molecular pathways and cellular interactions with potential clinical interest. Mutations at the initial site of colorectal carcinogenesis, such as p53 and APC, neoplastic cell interrelationship with the stromal macrophages, neoangiogenesis through growth factors, such as the vascular endothelial growth factor and platelet-derived growth factor, the role of hepatic sinusoidal cells, such as Kupffer cells, the expression of adhesion molecules, including the selectins and the integrins, are all crucial stages/events within the metastatic process. The exploration and analysis of recent research data may contribute to a better understanding of their clinical significance and may lead to new therapeutic strategies.
Publish Date	2014-04-14 10:49
Citation	Paschos KA, Majeed AW, Bird NC. Natural history of hepatic metastases from colorectal cancer - pathobiological pathways with clinical significance. World J Gastroenterol 2014; 20(14): 3719-3737
URL	http://www.wjgnet.com/1007-9327/full/v20/i14/3719.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i14.3719

Full Article (PDF)	WJG-20-3719.pdf
Full Article (Word)	WJG-20-3719.doc
Manuscript File	5921-Review.doc
Answering Reviewers	5921-Answering reviewers.pdf
Copyright License Agreement	5921-Copyright assignment.pdf
Peer-review Report	5921-Peer reviews.pdf
Scientific Editor Work List	5921-Scientific editor work list.doc