BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
12/27/2020 5:30:53 AM | Browse: 1117 | Download: 2231
 |
Received |
|
2020-09-03 20:37 |
|
Peer-Review Started |
|
2020-09-03 20:38 |
|
First Decision by Editorial Office Director |
|
2020-09-15 22:16 |
|
Return for Revision |
|
2020-09-15 22:16 |
|
Revised |
|
2020-09-30 01:00 |
 |
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2020-10-20 12:29 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2020-10-20 21:22 |
|
Articles in Press |
|
2020-10-20 21:22 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2020-12-24 02:30 |
|
Publish the Manuscript Online |
|
2020-12-27 05:30 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Basic Study |
| Article Title |
Effects of normobaric cyclic hypoxia exposure on mesenchymal stem-cell differentiation–pilot study on bone parameters in elderly
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Marta Camacho-Cardenosa, José Manuel Quesada-Gómez, Alba Camacho-Cardenosa, Alejo Leal, Gabriel Dorado, Bárbara Torrecillas-Baena and Antonio Casado-Diaz |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Government of Extremadura GAEDAF Research Group |
GR18003 |
| Ministerio de Educación, Cultura y Deporte |
FPU15/00452 |
| Instituto de Salud Carlos III |
PI15/01857 |
| Instituto de Salud Carlos III |
PI18/01659 |
|
| Corresponding Author |
Marta Camacho-Cardenosa, PhD, Postdoc, Facultad Ciencias Del Deporte, Universidad De Extremadura, Av. Universidad, s/n , Cáceres 10003, Spain. mcamachocardenosa@unex.es |
| Key Words |
Normobaric cyclic hypoxia; Mesenchymal stem cells; cellular differentiation; Osteoblast; Adipocytes; Bone health |
| Core Tip |
Cyclic hypoxia (CH) can improve bone health in aging. Mesenchymal stem cells were induced to differentiate into osteoblasts or adipocytes, in hypoxia (3% O2) for 1, 2 or 4 h, 4 d a week. Older people were treated with 36 CH sessions of 16 min (simulating an altitude of 2500 m), for 18 wk. Exposure to longer periods of hypoxia inhibited mesenchymal stem cells differentiation, but increased osteoprotegerin/receptor activator for nuclear factor kappa B ligand expression in both cell types. CH increased total bone mineral density, but not fat content, in elderly. CH may improve bone health in elderly, due to its inhibitory effect on bone resorption, by increasing the osteoprotegerin/receptor activator for nuclear factor kappa B ligand ratio. |
| Publish Date |
2020-12-27 05:30 |
| Citation |
Camacho-Cardenosa M, Quesada-Gómez JM, Camacho-Cardenosa A, Leal A, Dorado G, Torrecillas-Baena B, Casado-Diaz A. Effects of normobaric cyclic hypoxia exposure on mesenchymal stem-cell differentiation–pilot study on bone parameters in elderly. World J Stem Cells 2020; 12(12): 1667-1690
|
| URL |
https://www.wjgnet.com/1948-0210/full/v12/i12/1667.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v12.i12.1667 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
