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Articles Published Processes
1/21/2021 3:12:07 AM | Browse: 606 | Download: 898
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Received |
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2020-09-01 03:05 |
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Peer-Review Started |
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2020-09-01 03:05 |
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To Make the First Decision |
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Return for Revision |
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2020-09-15 22:35 |
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Revised |
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2020-11-01 01:10 |
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Second Decision |
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2020-11-17 12:25 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-11-17 22:54 |
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Articles in Press |
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2020-11-17 22:54 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-11-30 23:54 |
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Typeset the Manuscript |
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2021-01-18 06:21 |
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Publish the Manuscript Online |
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2021-01-21 03:12 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Transcriptomic alterations underline aging of osteogenic bone marrow stromal cells
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Yu-Hao Cheng, Shu-Fen Liu, Jing-Cheng Dong and Qin Bian |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81573992 |
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| Corresponding Author |
Qin Bian, MD, PhD, Professor, Department of Integrative Medicine, Huashan Hospital, Fudan University, Middle Wulumuqi Rd, Shanghai 200040, China. bianqin213@126.com |
| Key Words |
Bone marrow stromal cell; Mesenchymal stem cell; Mesenchymal stromal cell; Aging; Bone modeling and remodeling; Transcriptome |
| Core Tip |
Multipotent bone marrow stromal cells (BMSCs) are adult stem cells that form functional osteoblasts and play a critical role in bone remodeling. During aging, an increase in bone loss and reduction in structural integrity lead to osteoporosis and result in an increased risk of fracture. In this study, we examined age-dependent histological changes in murine vertebrae and uncovered that bone loss begins as early as the age of one month. The BMSCs isolated at different ages revealed a consistent decreasing trend in both colony-forming and osteogenic commitment capacity. Moreover, we obtained the transcriptomic profiles of BMSCs at 1 mo, 3 mo, and 7 mo to investigate the distinct molecular and regulatory features underpin the early loss of osteogenic potential. We showed the enrichment of osteoblastic regulation genes at one month and loss of osteogenic features at three months. The adipogenic and DNA repair features were enriched in the later age at seven months. Moreover, we demonstrated that the WNT and MAPK signaling pathways were upregulated at one month, followed by increased pro-inflammatory and apoptotic features. |
| Publish Date |
2021-01-21 03:12 |
| Citation |
Cheng YH, Liu S, Dong JC, Bian Q. Transcriptomic alterations underline aging of osteogenic bone marrow stromal cells. World J Stem Cells 2021; 13(1): 128-138 |
| URL |
https://www.wjgnet.com/1948-0210/full/v13/i1/128.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v13.i1.128 |
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