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12/4/2020 6:04:55 AM | Browse: 402 | Download: 1021
Publication Name World Journal of Gastroenterology
Manuscript ID 59357
Country/Territory China
Received
2020-09-17 14:36
Peer-Review Started
2020-09-17 14:36
To Make the First Decision
Return for Revision
2020-10-17 23:06
Revised
2020-10-30 02:44
Second Decision
2020-11-06 10:15
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-11-09 00:56
Articles in Press
2020-11-09 00:56
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-11-13 02:40
Typeset the Manuscript
2020-12-02 13:05
Publish the Manuscript Online
2020-12-04 06:04
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Transplantation
Manuscript Type Retrospective Cohort Study
Article Title High mortality associated with gram-negative bacterial bloodstream infection in liver transplant recipients undergoing immunosuppression reduction
Manuscript Source Unsolicited Manuscript
All Author List Fang Chen, Xiao-Yun Pang, Chuan Shen, Long-Zhi Han, Yu-Xiao Deng, Xiao-Song Chen, Jian-Jun Zhang, Qiang Xia and Yong-Bing Qian
ORCID
Author(s) ORCID Number
Fang Chen http://orcid.org/0000-0002-7941-9802
Xiao-Yun Pang http://orcid.org/0000-0003-0202-6290
Chuan Shen http://orcid.org/0000-0002-1317-8866
Long-Zhi Han http://orcid.org/0000-0003-4403-0909
Yu-Xiao Deng http://orcid.org/0000-0003-2401-1495
Xiao-Song Chen http://orcid.org/0000-0003-4540-7317
Jian-Jun Zhang http://orcid.org/0000-0002-9853-3416
Qiang Xia http://orcid.org/0000-0001-9482-6951
Yong-Bing Qian http://orcid.org/0000-0003-4081-428x
Funding Agency and Grant Number
Funding Agency Grant Number
National Key R&D Precision Medicine Program 2017YFC0908100
Shanghai Key Clinical Specialty Grant Shslczdzk05801
Corresponding Author Yong-Bing Qian, MD, Associate Professor, Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, No. 1630, Dongfang Road, Shanghai 200127, China. qianyb79@hotmail.com
Key Words Immunosuppressive therapy; Liver transplantation; Bloodstream infection; Multidrug-resistant gram-negative bacterium; ;
Core Tip Bacterial infections are the most common infectious complication after liver transplantation (LT). Immunosuppression (IS) reduction is usually needed in case of bacterial infections in LT recipients. However, we do not know exactly the incidence of IS reduction during bloodstream infection after LT and its effect on patient outcome. This single-center analysis summarized the IS reduction data in 70 LT recipients. We found IS reduction is more frequently associated with gram-negative bacterial infection than gram-positive bacterial infection in LT recipients. Complete withdrawal of immunosuppression should be cautious due to increased risk of mortality.
Publish Date 2020-12-04 06:04
Citation Chen F, Pang XY, Shen C, Han LZ, Deng YX, Chen XS, Zhang JJ, Xia Q, Qian YB. High mortality associated with Gram-negative bacterial bloodstream infection in liver transplant recipients undergoing immunosuppression reduction. World J Gastroenterol 2020; 26(45): 7191-7203
URL https://www.wjgnet.com/1007-9327/full/v26/i45/7191.htm
DOI https://dx.doi.org/10.3748/wjg.v26.i45.7191
Full Article (PDF) WJG-26-7191.pdf
Full Article (Word) WJG-26-7191.docx
STROBE Statement 59357-STROBE-Statement-revision.docx
Manuscript File 59357-Review-Filipodia.docx
Answering Reviewers 59357-Answering reviewers.pdf
Audio Core Tip 59357-Audio core tip.m4a
Biostatistics Review Certificate 59357-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 59357-Conflict-of-interest statement.pdf
Copyright License Agreement 59357-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 59357-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 59357-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 59357-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 59357-Language certificate.pdf
Peer-review Report 59357-Peer-review(s).pdf
Scientific Misconduct Check 59357-Scientific misconduct check.pdf
Scientific Editor Work List 59357-Scientific editor work list.pdf