Publication Name	World Journal of Gastroenterology
Manuscript ID	5938
Country	United States

Received	2013-10-06 18:42
Peer-Review Started	2013-10-08 10:51
To Make the First Decision	2013-12-03 19:09
Return for Revision	2013-12-16 16:13
Revised	2014-01-08 02:38
Second Decision	2014-03-06 17:47
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-03-06 18:21
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-03-31 15:26
Publish the Manuscript Online	2014-04-17 13:27

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Topic Highlights
Article Title	Genetic variations in colorectal cancer risk and clinical outcome
Manuscript Source	Invited Manuscript
All Author List	Kejin Zhang, Jesse Civan, Sushmita Mukherjee, Fenil Patel and Hushan Yang
Funding Agency and Grant Number	Funding Agency Grant Number Thomas Jefferson University National Cancer Institute CA162201
Corresponding Author	Hushan Yang, PhD, Division of Population Science, Department of Medical Oncology, Kimmel Cancer Center, Thomas Jefferson University, 111 S 11th St, Philadelphia, PA 19107, United States. hushan.yang@jefferson.edu
Key Words	Colorectal cancer; Genome-wide association study; Single nucleotide polymorphism; Signal transduction pathways; Cell cycle control; Gene desert; Genome instability
Core Tip	This review covers the recent advances in genome-wide association studies (GWASs) that have identified genetic variants associated with an altered risk of colorectal cancer (CRC). In this review, we summarize single nucleotide polymorphisms (SNPs) located in or near genes that play crucial roles in signal transduction pathways, genome stability, cell cycle control, and gene expression and regulation. SNPs that are found in gene desert regions are also discussed. The relationship between genetic variations and clinical outcomes in CRC is presented from epidemiological studies that have identified SNPs with methods other than GWASs.
Publish Date	2014-04-17 13:27
Citation	Zhang K, Civan J, Mukherjee S, Patel F, Yang H. Genetic variations in colorectal cancer risk and clinical outcome. World J Gastroenterol 2014; 20(15): 4167-4177
URL	http://www.wjgnet.com/1007-9327/full/v20/i15/4167.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i15.4167

Full Article (PDF)	WJG-20-4167.pdf
Full Article (Word)	WJG-20-4167.doc
Manuscript File	5938-Review.docx
Answering Reviewers	5938-Answering reviewers.pdf
Copyright License Agreement	5938-Copyright assignment.pdf
Peer-review Report	5938-Peer reviews.pdf
Scientific Editor Work List	5938-Scientific editor work list.doc