Publication Name	World Journal of Gastroenterology
Manuscript ID	5946
Country	United Kingdom

Received	2013-09-28 22:02
Peer-Review Started	2013-09-30 13:07
To Make the First Decision	2013-11-12 19:02
Return for Revision	2013-11-15 14:18
Revised	2013-12-03 01:07
Second Decision	2014-01-15 20:22
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-01-15 20:38
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-02-28 20:03
Publish the Manuscript Online	2014-03-18 14:14

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Virology
Manuscript Type	Topic Highlights
Article Title	Establishment of chronic hepatitis C virus infection: Translational evasion of oxidative defence
Manuscript Source	Invited Manuscript
All Author List	Shiu-Wan Chan
Funding Agency and Grant Number
Corresponding Author	Shiu-Wan Chan, PhD, Faculty of Life Sciences, The University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, United Kingdom. shiu-wan.chan@manchester.ac.uk
Key Words	Hepatitis C virus; Oxidative stress; Hydrogen peroxide; Translation; Internal ribosome entry site; Chronicity; Persistence
Core Tip	Oxidative stress inhibits canonical translation, however, emerging evidence suggests that oxidative stress can actually stimulate alternative translation from select internal ribosome entry site (IRES) elements including that involved in redox regulation and in persistent virus infection e.g., human immunodeficiency virus and hepatitis C virus (HCV). We postulate a novel role of oxidative stress-activated IRES-mediated translation in redox homeostasis and virus persistence. In the case of HCV, we explore the idea that HCV exploits oxidative stress to activate its own translation as a novel means of evading the host oxidative defence to establish chronicity.
Publish Date	2014-03-18 14:14
Citation	Chan SW. Establishment of chronic hepatitis C virus infection: Translational evasion of oxidative defence. World J Gastroenterol 2014; 20(11): 2785-2800
URL	http://www.wjgnet.com/1007-9327/full/v20/i11/2785.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i11.2785

Full Article (PDF)	WJG-20-2785.pdf
Full Article (Word)	WJG-20-2785.doc
Manuscript File	5946-Review.doc
Answering Reviewers	5946-Answering reviewers.pdf
Copyright License Agreement	5946-Copyright assignment.pdf
Peer-review Report	5946-Peer reviews.pdf
Scientific Editor Work List	5946-Scientific editor work list.doc