Publication Name	World Journal of Gastroenterology
Manuscript ID	5949
Country	Japan

Received	2013-09-28 22:08
Peer-Review Started	2013-09-30 09:28
To Make the First Decision	2013-10-14 21:05
Return for Revision	2013-10-17 11:23
Revised	2013-11-12 15:28
Second Decision	2014-01-15 20:22
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-01-15 20:39
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-02-28 13:47
Publish the Manuscript Online	2014-03-12 14:46

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Exenatide improves hepatic steatosis by enhancing lipid use in adipose tissue in nondiabetic rats
Manuscript Source	Invited Manuscript
All Author List	Kosuke Tanaka, Yuko Masaki, Masatake Tanaka, Masayuki Miyazaki, Munechika Enjoji, Makoto Nakamuta, Masaki Kato, Masatoshi Nomura, Toyoshi Inoguchi, Kazuhiro Kotoh and Ryoichi Takayanagi
Funding Agency and Grant Number
Corresponding Author	Masaki Kato, MD, Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. mkato11@intmed3.med.kyushu-u.ac.jp
Key Words	Adipose tissue; Energy expenditure; Exenatide; Glucagon-like peptide-1; Hepatic steatosis; Lipolysis; Nonalcoholic fatty liver disease
Core Tip	Glucagon-like peptide-1 (GLP-1) is reported to improve nonalcoholic fatty liver disease (NAFLD), mainly via direct action on the liver. However, organs other than the liver may also be involved in regulation of hepatic lipid contents. In this study, we found significant upregulation of lipolytic genes in adipose tissue in exenatide-treated NAFLD rats. Up-regulation of catalase, superoxide dismutase and mitochondrial morphological regulators was observed in adipose tissue. These metabolic changes were accompanied by increased oxygen consumption and decreased respiratory exchange ratio. Taken together, enhanced lipid use by GLP-1 in adipose tissue may play an important role in the improvement of NAFLD.
Publish Date	2014-03-12 14:46
Citation	Tanaka K, Masaki Y, Tanaka M, Miyazaki M, Enjoji M, Nakamuta M, Kato M, Nomura M, Inoguchi T, Kotoh K, Takayanagi R. Exenatide improves hepatic steatosis by enhancing lipid use in adipose tissue in nondiabetic rats. World J Gastroenterol 2014; 20(10): 2653-2663
URL	http://www.wjgnet.com/1007-9327/full/v20/i10/2653.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i10.2653

Full Article (PDF)	WJG-20-2653.pdf
Full Article (Word)	WJG-20-2653.doc
Manuscript File	5949-Review.docx
Answering Reviewers	5949-Answering reviewers.pdf
Copyright License Agreement	5949-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	5949-Language certificate.pdf
Peer-review Report	5949-Peer reviews.pdf
Scientific Editor Work List	5949-Scientific editor work list.doc