Publication Name	World Journal of Gastroenterology
Manuscript ID	5956
Country	Taiwan

Received	2013-09-28 22:40
Peer-Review Started	2013-09-29 08:27
To Make the First Decision	2013-11-21 20:57
Return for Revision	2013-11-22 10:03
Revised	2013-12-05 20:29
Second Decision	2014-04-03 10:14
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-04-03 12:29
Articles in Press	2014-05-23 12:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-06-03 18:17
Publish the Manuscript Online	2014-06-21 13:56

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Virology
Manuscript Type	Topic Highlights
Article Title	Production and pathogenicity of hepatitis C virus core gene products
Manuscript Source	Invited Manuscript
All Author List	Hui-Chun Li, Hsin-Chieh Ma, Chee-Hing Yang and Shih-Yen Lo
Funding Agency and Grant Number	Funding Agency Grant Number National Science Council of Taiwan NSC 101-2320-B-320-011 (to Lo SY) Tzu Chi University TCMRC-P-101015 (to Li HC and Lo SY) Tzu Chi University TCRPP101017 (to Li HC and Lo SY)
Corresponding Author	Shih-Yen Lo, Professor, Department of Laboratory Medicine and Biotechnology, Tzu Chi University, 701, Section 3, Chung Yang Road, Hualien 97004, Taiwan. losylo@mail.tcu.edu.tw
Key Words	Hepatitis C virus; Core protein; Alternative reading frame/core+1 proteins; Insulin resistance; Steatosis; Hepatocellular carcinoma; Interferon
Core Tip	In addition to the mature core protein (a.a. 1-177) and the cleaved peptide (a.a. 178-191), different alternative reading frame (ARF)/core+1 proteins could be expressed from the core+1 reading frame of hepatitis C virus (HCV) core gene. Core gene products play an important role in the HCV pathogenesis. Core protein could induce insulin resistance, steatosis, and even hepatocellular carcinoma. The peptide (a.a. 178-191) may play a role in the immune response and steatosis development. ARF proteins/core+1/F protein could enhance hepatocyte growth and may regulate iron metabolism. We summarized the current knowledge regarding the HCV core gene products and their pathogenicity in this article.
Publish Date	2014-06-21 13:56
Citation	Li HC, Ma HC, Yang CH, Lo SY. Production and pathogenicity of hepatitis C virus core gene products. World J Gastroenterol 2014; 20(23): 7104-7122
URL	http://www.wjgnet.com/1007-9327/full/v20/i23/7104.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i23.7104

Full Article (PDF)	WJG-20-7104.pdf
Full Article (Word)	WJG-20-7104.doc
Manuscript File	5956-Review.docx
Answering Reviewers	5956-Answering reviewers.pdf
Copyright License Agreement	5956-Copyright assignment.pdf
Peer-review Report	5956-Peer reviews.pdf
Scientific Editor Work List	5956-Scientific editor work list.doc