| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Emergency Medicine |
| Manuscript Type |
Basic Study |
| Article Title |
Pretreatment with intestinal trefoil factor alleviates stress-induced gastric mucosal damage via Akt signaling
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yun Huang, Meng-Meng Wang, Zhi-Zhou Yang, Yi Ren, Wei Zhang, Zhao-Rui Sun and Shi-Nan Nie |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Social Development Projects of Jiangsu Province |
BE2017720 |
| National Natural Science Foundation of China |
81701894 |
| Jiangsu Provincial Medical Youth Talent |
QNRC2016909 |
| Natural Science Foundation of Jiangsu Province |
BK20190247 |
| Science Foundation of Jiangsu Health Commission |
H2018039 |
| China Postdoctoral Science Foundation |
2018M643890 |
| Jiangsu Postdoctoral Science Foundation |
2018K048A |
| Jiangsu Provincial Medical Youth Talent |
QNRC2016908 |
| Jiangsu Postdoctoral Science Foundation |
2020Z193 |
|
| Corresponding Author |
Shi-Nan Nie, MD, PhD, Director, Director, Professor, Department of Emergency Medicine, Jinling Hospital, Medical School of Nanjing University, No. 305 East Zhongshan Road, Nanjing 210002, Jiangsu Province, China. shn_nie@sina.com |
| Key Words |
Intestinal trefoil factor; Water immersion restraint stress; Gastric mucosa; Epithelium integrity; Akt signaling pathway |
| Core Tip |
Stress-related gastric mucosal damage remains an issue for critical care patients. As an endogenous peptide, intestinal trefoil factor was found to alleviate both macroscopic and microscopic gastric mucosal damage in vivo induced by acute stress stimulation, and promote mucosal epithelial cell survival, accelerate wound closure, and preserve mucosal integrity in vitro, in which the Akt signaling pathway could play the essential roles. Therefore, intestinal trefoil factor was a promising candidate for prevention and treatment of stress-induced gastric mucosal damage. |
| Publish Date |
2020-12-25 10:20 |
| Citation |
Huang Y, Wang MM, Yang ZZ, Ren Y, Zhang W, Sun ZR, Nie SN. Pretreatment with intestinal trefoil factor alleviates stress-induced gastric mucosal damage via Akt signaling. World J Gastroenterol 2020; 26(48): 7619-7632 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i48/7619.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i48.7619 |
