Publication Name	World Journal of Gastroenterology
Manuscript ID	5964
Country	Japan

Received	2013-09-29 08:52
Peer-Review Started	2013-10-04 16:08
To Make the First Decision	2013-11-04 19:08
Return for Revision	2013-11-05 09:24
Revised	2013-11-12 19:08
Second Decision	2013-12-13 14:04
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-12-13 15:00
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-01-14 16:33
Publish the Manuscript Online	2014-01-26 20:08

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Accumulation of aberrant DNA methylation during colorectal cancer development
Manuscript Source	Invited Manuscript
All Author List	Eiji Sakai, Atsushi Nakajima and Atsushi Kaneda
Funding Agency and Grant Number
Corresponding Author	Atsushi Kaneda, MD, PhD, Department of Molecular Oncology, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba-City 260-8670, Japan. kaneda@chiba-u.jp
Key Words	Colorectal cancer; Colorectal adenoma; Aberrant crypt foci; Genetic mutation; Epigenotype; DNA methylation; Colorectal carcinogenesis
Core Tip	Colorectal cancer (CRC) is a heterogeneous disease which involves several distinct molecular carcinogenetic pathways. Recent comprehensive genome-wide analyses clarify detailed DNA methylation statuses of cancer-related genes in CRC. We and others have investigated the association between DNA methylation and genetic alterations, and performed classification of CRC/their precursors, including conventional adenomas, serrated adenomas, non-polypoid colorectal neoplasms and aberrant crypt foci. In addition, we also evaluated the usefulness of DNA methylation markers as surrogate biomarkers for diagnosis, prognosis and therapeutic application of CRC. Here, we review the DNA methylation status and classification of CRC to understand the roles of DNA methylation in colorectal carcinogenesis.
Publish Date	2014-01-26 20:08
Citation	Sakai E, Nakajima A, Kaneda A. Accumulation of aberrant DNA methylation during colorectal cancer development. World J Gastroenterol 2014; 20(4): 978-987
URL	http://www.wjgnet.com/1007-9327/full/v20/i4/978.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i4.978

Full Article (PDF)	WJG-20-978.pdf
Full Article (Word)	WJG-20-978.doc
Manuscript File	5964-Review.doc
Answering Reviewers	5964-Answering reviewers.pdf
Copyright License Agreement	5964-Copyright assignment.pdf
Peer-review Report	5964-Peer reviews.pdf
Scientific Editor Work List	5964-Scientific editor work list.doc