Publication Name	World Journal of Gastroenterology
Manuscript ID	5970
Country	Italy

Received	2013-09-29 09:17
Peer-Review Started	2013-10-02 11:45
First Decision by Editorial Office Director
Return for Revision	2013-12-17 15:08
Revised	2014-01-18 20:33
Publication Fee Transferred
Second Decision by Editor	2014-04-03 10:14
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-04-03 12:30
Articles in Press	2014-05-23 11:05
Edit the Manuscript by Language Editor	2014-05-05 16:32
Typeset the Manuscript	2014-06-10 15:34
Publish the Manuscript Online	2014-06-27 10:37

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Psychiatry
Manuscript Type	Topic Highlights
Article Title	Role of negative affects in pathophysiology and clinical expression of irritable bowel syndrome
Manuscript Source	Invited Manuscript
All Author List	Maria Rosaria A Muscatello, Antonio Bruno, Giuseppe Scimeca, Gianluca Pandolfo and Rocco A Zoccali
Funding Agency and Grant Number
Corresponding Author	Rocco A Zoccali, Professor, Psychiatry Unit, Department of Neurosciences, University of Messina, Via Consolare Pompea, 1, 98125 Messina, Italy. rocco.zoccali@unime.it
Key Words	Depression; Anxiety; Anger; Mood disorders; Irritable bowel syndrome; Neuroticism; Stress; Brain-gut axis; Microbiota; Hypothalamic-pituitary-adrenal axis
Core Tip	This review deals with the role of negative affects in pathophysiology and clinical expression of irritable bowel syndrome (IBS). Depression, anxiety, and anger play a key role in dysregulation of the brain-gut axis, contributing to the majority of pathophysiological and symptomatic correlates of IBS. Research efforts to integrate different knowledge provide further insight into the pathways linking negative psychological states to health and disease, leading to identification of individual vulnerability and susceptibility factors, including subsyndromal conditions, which should be addressed to promote better health in the population and more effective and efficient prevention and treatment of IBS.
Publish Date	2014-06-27 10:37
Citation	Muscatello MRA, Bruno A, Scimeca G, Pandolfo G, Zoccali RA. Role of negative affects in the pathophysiology and clinical expression of irritable bowel syndrome. World J Gastroenterol 2014; 20(24): 7570-7586
URL	http://www.wjgnet.com/1007-9327/full/v20/i24/7570.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i24.7570

Full Article (PDF)	WJG-20-7570.pdf
Full Article (Word)	WJG-20-7570.doc
Manuscript File	5970-Review.doc
Answering Reviewers	5970-Answering reviewers.pdf
Copyright License Agreement	5970-Copyright assignment.pdf
Peer-review Report	5970-Peer reviews.pdf
Scientific Editor Work List	5970-Scientific editor work list.doc