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Articles Published Processes
2/6/2021 11:08:07 AM | Browse: 485 | Download: 964
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Received |
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2020-09-24 15:56 |
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Peer-Review Started |
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2020-09-24 15:57 |
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To Make the First Decision |
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Return for Revision |
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2020-12-08 08:16 |
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Revised |
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2020-12-08 09:05 |
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Second Decision |
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2020-12-17 12:25 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-12-23 05:01 |
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Articles in Press |
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2020-12-23 05:01 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-01-21 02:06 |
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Publish the Manuscript Online |
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2021-02-06 11:08 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Report |
| Article Title |
Wilson disease — the impact of hyperimmunity on disease activity: A case report
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wolfgang Stremmel, Thomas Longerich, René Liere, Vladimir Vacata, Josef van Helden and Ralf Weiskirchen |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Wolfgang Stremmel, MD, Senior Scientist, Department of Gastroenterology and Hepatology, Medical Center Baden-Baden, Im Neuenheimer Feld 410, Baden-Baden D-76530, Germany. wolfgangstremmel@aol.com |
| Key Words |
Wilson disease; Copper metabolism; Antinuclear antibodies; Diagnosis; Steroid therapy; Case report |
| Core Tip |
Variable courses of metabolic liver diseases remain obscure. A 9-year-old girl with Wilson disease had concomitant antinuclear antibodies elevation without immunoglobulin G elevation. Already after one year of therapy with copper chelators the free copper as treatment target was normalized as well as transaminases. Six years later transaminases (alanine aminotransferase) rose despite normalized free copper up to 571 U/L in December 2019. A short-term steroid therapy, improved transaminases significantly. As underlying course, such a neglected hyperimmune state without immunoglobulin elevation was verified in a cohort of 5.789 liver disease patients and may represent a new entity explaining liver disease activation. |
| Publish Date |
2021-02-06 11:08 |
| Citation |
Stremmel W, Longerich T, Liere R, Vacata V, van Helden J, Weiskirchen R. Wilson disease — the impact of hyperimmunity on disease activity: A case report. World J Clin Cases 2021; 9(6): 1386-1393 |
| URL |
https://www.wjgnet.com/2307-8960/full/v9/i6/1386.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v9.i6.1386 |
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